Effect of Corchorus Olitorius Extract On Haematological and Plasma Biochemical Parameters in Male Albino Rats

Abstract

The effect of oral administration of aqueous extract of Corchorus olitorius (AECO) at doses of 250 mg/kg BW, 500 mg/kg BW and 750 mg/kg BW on haematological and plasma biochemical parameters in male albino rats were investigated. The extract was administered on daily basis for 30 days and blood samples were collected for haematological and plasma biochemical assays. Treatment of rats for 30 days with all the treatment doses (250 mg/kg BW, 500 mg/kg BW, 750 mg/kg BW) of AECO caused insignificant (p>0.05) changes in PCV, RBC, MCV, MCHC, MCH, platelet, neutrophil, lymphocyte, eosinophil and monocyte values relative to their respective controls, but caused significant (p<0.05) decrease in TWBC count relative to the control. Treatment of rats with 750 mg/kg BW of AECO cause significant (p<0.05) increase in total protein level relative to the control, but 250 mg/kg BW and 500 mg/kg BW of AECO caused significant (p<0.05) reductions in globulin levels. These findings suggest that aqueous extract of Corchorus olitorius could have both harmful and beneficial potentialities on the blood chemistry of male albino rats.