Effect of Justicia spicigera extract plant on oxidative and nitrosative stress in hypertensive rat kidney mitochondria (960.2)

Abstract

Hypertension is a major risk factor for cardiovascular, Reno vascular disease. Reduction of elevated blood pressure significantly reduces the risk of cardiovascular events. Kidney synthesizes reactive oxygen species (ROS), which under pathological conditions play an important role in renal dysfunction. Evidence indicates that increased oxidative and nitrosative stress are mediators of Reno vascular injury in cardiovascular pathologies. Herbal medicines are being used by about 80% of the world population for the primary health care including hypertension. Recent data demonstrated that Justicia spicigera (muicle) a Mexican medicinal plant, has a potential to reduce the blood pressure in L‐NAME rats through the chloroform extract, hence the main purpose of this work was to elucidate if the oxidative and nitrosative stress are related with the antihypertensive effect of Justicia spicigera, however our results indicate that the stress levels assayed by lipid peroxidation, nitric oxide and protein nitration (S‐nitrosylation) are no different in hypertensive and control groups. In conclusion, part of the mechanism by which muicle reduces blood pressure is not mediated by ROS. Acknowledgements: We appreciated the partial economic support from the grants of: CIC‐UMSNH (2.10 to RSG; 2.16 to ASM; 2.33 to SMA) and CONACYT (169093 to ASM). EEG is a CIC‐UMSNH Postdoctoral Fellow.