Abstract
1. 1. A cell-free system from Mycobacterium smegmatis ATCC-607 capable of polypeptide synthesis is described. Although the system exhibited a low level of endogenous activity, it showed a marked stimulation in phenylalanine incorporation mediated by polyuridylic acid (100 μg) at 15 mM magnesium. 2. 2. In such a system, addition of isoniazid was found to alter the translation rate of polyuridylic acid stimulation. 3. 3. Evidence is presented showing that variation in the synthesis of polyphenylalanine in the presence of isoniazid is due to an effect on the rate of charging of the aminoacyl-tRNA.
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