Abstract
Daily intraperitoneal administration of hexavalent chromium (Cr 6+; 1, 2, and 3 mg/kg intraperitoneally as potassium dichromate) in weaned rats for an entire duration of 55 and 90 days of age produced dose- and duration-dependent enzymatic and pathologic alterations. At 55 days, the pathologic changes were not seen in testes of Cr 6+ treated rats, but the activities of sorbitol dehydrogenase, lactic dehydrogenase, λ-glutamyl transpeptidase, and glucose-6-phosphate dehydrogenase were significantly altered. When the treatment was prolonged to sexual maturity, that is, 90 days of age, the alterations in enzyme activities were greater, and there were dose-dependent pathologic changes in the testes of Cr 6+-treated rats. These alterations suggest a risk to growing testes if rats are exposed to Cr 6+ during the prepubertal stage of development, which, in turn, may disturb normal testicular physiology at adulthood.
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