Abstract
The mechanism by which exercise reduces visceral fat is not fully understood. We have reported that increase in serum growth hormone (GH) level by mild exercise is associated with increase in lipolysis in type 2 diabetes (T2D), and that GH stimulates lipolysis in rat visceral adipose tissue. The aim of this study was to investigate the effect of GH secretion in response to exercise on visceral fat in obese subjects with T2D. Subjects were divided into exercise (n = 11) and non-exercise (n = 8) groups. Exercise was performed at anaerobic threshold (AT). Blood samples were obtained at weeks 0 and 4. To evaluate the secretion of GH and catecholamines in response to exercise, serum GH and catecholamines levels were measured before and after a bout of exercise on day 1. Visceral fat area (VFA) reduction tended to be greater in exercise group compared to non-exercise group (p = 0.067), whereas subcutaneous fat area (SFA) reduction was not different between two groups. In exercise group, serum GH level tended to increase during exercise, while catecholamines showed no significant changes. The change in serum GH level correlated negatively with the change in VFA during this study, but did not correlate with SFA. The increase in serum insulin-like growth factor-I level in exercise group was 10-fold higher than that in non-exercise group. These results suggest that in obese patients with T2D, exercise performed at AT may reduce visceral fat and the reduction appears to be associated with GH secretion but not with catecholamine in response to exercise.:
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