Abstract
In the present study the effects of somatostatin on serum growth hormone (GH) levels in the goldfish, Carassius auratus, were investigated. A single intraperitoneal injection of either 0.1 or 1.0 μg somatostatin/g body wt caused a significant decrease in serum GH levels at 1 h postinjection compared to vehicle-injected controls. Two intraperitoneal injections of somatostatin (1.0 μg/g body wt), given 12 hr apart, caused a significant decrease in serum GH levels, compared to both presample and vehicle-injected control groups at 1.5 and 6 hr following the second injection. In fish given two injections of somatostatin, a post inhibitory rebound in serum GH levels occurred by 24 hr following the second injection. Thyrotropin-releasing hormone (1 μg/g body wt), given as a control peptide, caused a significant increase in serum GH levels at 24 hr, but no significant changes were found at 1.5 or 6 hr following the second of two intraperitoneal injections given 12 hr apart. The increases in serum GH at 24 hr may be due to stress. The results demonstrate that somatostatin causes a transient decrease in blood GH levels in goldfish.
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