Effect of Endotoxemia on Cardiac Disease in High and Low Flux Hemodialysis Patients

Abstract

Background : endotoxemia can be the missing link between ESRD and cardiac disease , the first cause of death in hemodialysis patients . Patients and methods : patients were recruited from Ain Shams University Hospitals , hemodialysis units .120 patients on prevalent HD were enrolled in the study : 31 cardiac patients on high flux HD ( group A) , 29 cardiac patients on low flux HD (group B), 32 non – cardiac high flux HD ( group C), and 28 non – cardiac low flux HD ( group D) . For all patients we measured : Hb , URR , serum albumin , HsCRP, predialysis and postdialysisa endotoxin , endotoxin delta change, echocardiography , and ECG . Results : we found that cardiac high flux and low flux groups had higher endotoxemia levels than non – cardiac high flux and low flux groups .Conclusion : High flux hemodialysis patients had higher accumulated endotoxin than low flux hemodialysis patients, within either cardiac or non - cardiac groups .