Effect of early application of simvastatin on hypertension with COPD

Abstract

Objective To study the effect of early application of simvastatin on hypertension with chronic obstructive pulmonary disease (COPD). Methods A total of 82 hypertensive patients with COPD in our hospital were selected as study subjects and divided into the control group and the study group according to different treatment methods, 41 cases in each group. The control group were treated with routine therapy, and the study group were additionally treated with simvastatin. The right ventricular Tei index, pulmonary function indexes, serum NO and CRP were compared between the two groups. Results The right ventricular Tei index, PAPm, and serum CRP level in the study group [(0.47±0.07), (30.36±2.15)mmHg, (13.15±7.06) mg/L] were significantly lower than those in the control group [(0.53±0.13), (33.78±1.06)mmHg, (19.23±7.47)mg/L], while FEV1, FVC, and serum NO level [(68.31±15.28)%, (2.29±0.81)L, (55.17±9.03)mg/L] were significantly higher than those in the control group [(60.56±14.34)%, (1.82±0.79)L, (45.96±7.62)mg/L] (P<0.05). Conclusion Early application of simvastatin has definite therapeutic effect on hypertension and COPD, which can significantly improve the cardiopulmonary function, serum NO and CRP levels in patients. Key words: Simvastatin; Hypertension; Chronic obstructive pulmonary disease; Effect