Investigation of Serum NO, ADMA and Apelin Levels in Thyroid Dysfunction

Arzu Şahin ,Mustafa Gül ,Elif Şimşek ,Ömer Akyol ,Fikret Çelebi ,Akar Karakoç

doi:10.7176/jmpb/67-03

Abstract

Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries. It was aimed to investigate serum NO, ADMA and Apelin levels in patients with thyroid dysfunction. This study was conducted with 150 thyroid patients and 50 healthy subjects. Study subjects were divided into three groups; control (n=50), hyperthyroid ( n=75) and hypothyroid (n=75). Serum TSH, FT3, FT4 levels were measured by chemiluminescence method NO level were measured by spectrophotometric method, ADMA and apelin levels were measured by ELISA. Serum NO levels were higher in hypothyroid group than in hyperthyroid group, and the difference was statistically significant. Serum ADMA levels of the hyperthyroid group were significantly higher than the other two groups and the difference was statistically significant. The levels of serum apelin were statistically significantly higher in the hyperthyroid group than the other two groups. In patients with hyperthyroidism, ADMA and Apelin levels were higher, while NO level was lower. However, NO level was higher in patients with hypothyroidims than the other two groups. Apelin, which has been emphasized as a preventive and therapeutic agent particularly for the cardiovascular system, might have increased in hyperthyroid patients, regardless of NO, to protect cardiovascular system from possible adverse effects of ADMA. Keywords: Asymmetric dimethylarginine, apelin, nitric oxide, thyroid dysfunction DOI: 10.7176/JMPB/67-03 Publication date: August 31 st 2020

Highlights

Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries (Arıkan et al.2007; Demers and Spercer 2003)
The aim of our study is to provide an insight on the etiopathogenesis of the relationship between thyroid dysfunction and cardiovascular diseases which has not been fully clarified yet by investigating the serum nitric oxide (NO), asymmetric dimethylarginine (ADMA) and apelin levels in thyroid dysfunction posing a significant risk for cardiovascular diseases
Hermenegildo et al(2002) investigated the plasma NO and ADMA levels in their study carried out on patients with thyroid dysfunction (Hemenegildo et al.2002). They reported that NO levels were determined at a lower level in the hyperthyroidism group compared to the hypothyroidism group and the control group, ADMA level was found to be higher in the hyperthyroidism group compared to other two groups

Summary

Introduction

Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries (Arıkan et al.2007; Demers and Spercer 2003). Thyroid diseases may lead to endothelial dysfunction; the mechanism underlying the endothelial dysfunction in thyroid disease is not clear yet (Gürel et al 2015; Obregon 2014). The thyroid dysfunction which is not sufficiently treated has been reported to be among the most common underlying causes of cardiovascular diseases. It has been stated that the timely identification of cardiac symptoms and effective treatment are required in patients with thyroid dysfunction (Gerdes et al 2010; Galli et al 2010; Biondi et al 2010). It has been reported that the early diagnosis of the pathological findings of cardiovascular diseases in patients with thyroid dysfunction can make significant contributions in the prevention of the development, prognosis and treatment of endothelial dysfunction and heart failure (Siu et al 2007; Bernadette 2012). Endothelial dysfunction occurs if this balance is disrupted. The disruption of the endothelial function is the earliest symptom which is the sign of coronary artery disease (Kinlay et al.2001)

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