Abstract
Objective To study the effect of early application of naloxone on serum high sensitivity C-reactive protein(hs-CRP)and S100B protein in neonates with hypoxic-ischemic encephalopathy. Methods According to the digital table,86 neonates with hypoxic-ischemic encephalopathy were randomly divided into the control group(n= 43 cases)and the observation group(n= 43 cases).The control group was treated by conventional therapy,while the observation group was treated by conventional therapy plus naloxone.They were treated for 7-10 days.The clinical effect was evaluated.Serum hs-CRP and S100B protein were detected before and after treatment .Results The total effective rate of the control group was 86.0%,which was significantly lower than 97.7% of the observation group(χ2= 5.78,P< 0.05).The sense of recovery,reflecting the recovery and muscle tension recovery time of the observation group were less than those in the control group(t = 5.017 2,3.991 6,2.904 8,all P< 0.05).After treatment,the serum hs-CRP and S100B protein in the two groups were significantly decreased(t= 6.776 2,10.903 8,7.772 8,11.092 6,all P< 0.01),compared with the control group,the decrease of the observation group was more significant(t= 3.368 2,3.092 8,all P< 0.05) Conclusion Early application of naloxone in neonates with hypoxic-ischemic encephalopathy can decrease serum hs-CRP and S100B protein. Key words: Naloxone; Brain injury,chronic; C-reactive protein; Calcium-binding proteins
Published Version
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