Abstract
Activity of succinic dehydrogenase and adenosine triphosphatase was significantly reduced and that of β-glucuronidase was increased in rat gonads after treatment with di-2-ethylhexyl phthalate (DEHP). Histopathological studies revealed focal degeneration of seminiferous tubules and edema of interstitium in testis but no detectable alterations in ovary of treated animals as compared to controls. Such alterations may perhaps be responsible for the reported reproductive dysfunction in experimental animals after exposure to this and other phthalate plasticizers.
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