Effect of dexmetomidine on postoperative analgesia in patients with colon cancer after minimally invasive surgery

Abstract

Objective To study the effect of dexmetomidine on postoperative analgesia in patients with colon cancer after minimally invasive surgery. Methods From January 2015 to March 2018, 78 patients with colon cancer treated in Shanxi Coal Central Hospital were randomly divided into the observation group and the control group, with 39 cases in each group.The control group was treated with fentanyl, and the observation group was treated with dexmedetomidine for analgesia.The analgesic effect and adverse reaction were observed and compared between the two groups. Results At 6 h, 12 h, 24 h, 48 h after operation, the resting pain VAS scores in the observation group[(2.2±0.8)points, (2.4±0.5)points, (2.1±0.5)points, (1.8±0.5)points]were significantly lower than those in the control group[(3.4±0.9)points, (3.7±0.8)points, (3.2±0.6)points, (2.7±0.5)points], the differences were statistically significant (t=2.241, 2.839, 2.580, 2.683, P=0.036, 0.004, 0.010, 0.007). At 6 h, 12 h, 24 h after operation, the VAS scores of active pain in the observation group[(1.3±0.6)points, (1.5±0.5)points, (1.1±0.4)points] were significantly lower than those of the control group[(1.7±0.5)points, (2.1±0.7)points, (1.7±0.6)points](t=2.521, 2.753, 2.683, P=0.015, 0.006, 0.007). The incidence rate of nausea of the observation group was 5.1%, which was significantly lower than 33.3% of the control group.There were no patients with vomiting and high blood pressure.The incidence rates of nausea and vomiting of the observation group were lower than those of the control group, the differences were statistically significant (χ2=4.841, 4.713, P=0.022, 0.031). Conclusion Dexmetomidine has significant analgesic effect on patients with colon cancer after minimally invasive surgery.It is safe and has no obvious adverse reaction. Key words: Colonic neoplasms; Surgical procedures, minimally invasive; Pain, postoperative; Analgesia; Dexmetidine; Pain measurement; Patient simulation; Contrastive study