Abstract

Objective To study the effect of dexmedetomidine on perioperative stress reaction and postoperative cellular immunity of patients with breast cancer radical surgery. Methods We selected 108 cases of breast cancer patients undergoing elective radical surgery under general anesthesia in our hospital from January 2012 to June 2015. These patients were divided into dexmedetomidine group (group D) and the control group (group C) by random number table method, 54 cases in each group. Patients in group D were given dexmedetomidine 1.0 μg/kg by intravenous drip within 15 min before anesthesia and maintained 0.5 μg.kg-1.h-1 after anesthesia induction intubation until operation finish. Patients in group C were given the same capacity of normal saline instead of dexmedetomidine, and the rest of the anesthesia was same as group D. The plasma norepinephrine (NE) and epinephrine (E) and cortisol (COR), serum interleukin-6 and T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+ /CD8+) and NK cells levels were determined before anesthesia (T0), postoperative 4 h (T1), 1 d (T2), 3 d (T3), and 7 d (T4). Results The level of plasma NE, E, COR and serum IL-6 of the D group in different time had no statistical significance compared with T0 time (P>0.05). The plasma level of E and NE in T1-T3, plasma COR in T2-T3 and serum IL-6 in T2-T4 of the C group were increased significantly (P<0.05). The level of plasma E and NE in T1-T3, plasma COR in T2-T3 and serum IL-6 in T2-T4 of the D group were decreased significantly compared with C group (P<0.05). The level of CD3+ and NK cells in T1-T3 of the two groups decreased significantly compared with T0 (P<0.05). The level of NK and CD3+ in T1-T3 and CD4+, CD4+ /CD8+ in T2-T3 of group D increased significantly compared with group C (P<0.05). Conclusion Dexmedetomidine of intravenous drip during general anesthesia can effectively reduce stress reaction in perioperative period of breast cancer patients, and improve patients immune status. Key words: Breast neoplasms; Stress; Epinephrine; Norepinephrine; T-lymphocytes; Dexmedetomidine

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.