Abstract
Objective To investigate the effects of different doses of dexmedetomidine on the stress response of patients undergoing general anesthesia during the awakening period. Methods A total of 120 patients scheduled for thoracotomy under general anesthesia were randomly divided into control group, middle dose group and high-dose group, with 40 cases in each group. The medium dose group was given 0.5 μg/(kg·h) dexmedetomidine, and the high dose group was given 0.8 μg/(kg·h)right metomimidine, and the observation group was given equal amount of saline. The changes of heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation (SpO2), blood glucose (Glu) and plasma cortisol (Cor) were compared between the three groups at the end of operation (T1), immediately after extubation (T2) and after extubation (5 min) (T3). Results At T1, T2, T3, the levels of HR, MAP in the three groups were significantly higher than those at T0 times (P 0.05). There was no significant change in SpO2 at each time point in each group (P>0.05). There was no significant change in the middle dose group and high dose group in blood glucose levels at each time point (P>0.05), the blood glucose levels in the control group at T3 was significantly higher than that at T0 (P<0.05). At T3, the plasma cortisol levels of the three groups were higher than those at T0 (P<0.05), and the plasma cortisol level at T3 time in the control group was significantly higher than that of the middle dose group and high dose group (P<0.05). The incidence of tachycardia in the control group was significantly higher than that in the middle dose group and the high-dose group (P<0.05), while the incidence of bradycardia in the high-dose group was significantly higher than that in the control group and the middle dose group (P<0.05). Conclusions Dexmedetomidine can effectively inhibit the stress response of the body in the awakening period of general anesthesia, and the medium dose dexmedetomidin has better clinical effect and less adverse reaction. Key words: Dexmedetomidine; Dose; Waking period; Stress response
Published Version
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