Abstract
Objective To explore the effect of combining immersion therapy with Shengji ointment on wound healing rate and adverse reaction rate (ARR) in patients with second-degree burn. Methods The data of 80 patients with second-degree burn treated in our hospital from February 2019 to February 2020 were retrospectively analyzed by the means of retrospective study, and the patients were equally divided into the treatment group and the control group according to their admission order, with 40 cases each. Immersion therapy was performed to all patients (7 d); after that, patients in the control group received routine medication (7 d), and those in the treatment group were treated with Shengji ointment until the wounds were healed, so as to compare their wound healing condition, ARRs, levels of inflammatory factors, and infection incidence. Results Compared with the control group after treatment, the treatment group presented significantly shorter wound healing time (12.14 ± 1.26 vs. 15.98 ± 1.20, P < 0.001), better wound healing rate and quality (P < 0.05), and lower levels of inflammatory factors (P < 0.001); no significant between-group difference in ARRs was shown (P > 0.05); 34 patients in the treatment group (85.0%) and 26 patients in the control group (65.0%) had no infections, so the incidence rate of infections was significantly lower in the treatment group than in the control group (P < 0.05). Conclusion Combining immersion therapy with Shengji ointment can reduce the levels of inflammatory factors in patients with second-degree burn, lower the incidence rate of infections, provide the conditions for wound healing, and increase the wound healing rate, which shall be promoted and applied in practice.
Highlights
Burn injury is tissue damage caused by heat, which is divided into first-degree burn, superficial second-degree burn, deep second-degree burn, and third-degree burn, of which the first-degree burn only injuries the epidermis and does not damage the germinal layer, so it can be healed in 3 to 5 days without scarring the skin [1, 2]
Scholars Fang M A et al used silver sulfadiazine as a control and applied the Qingre Shengji ointment that contained rhubarb, Chinese goldthread rhizome, baical skullcap root, and other herbs to rats with second-degree burn and found that the ointment could increase the content of vascular endothelial growth factor (VEGF) and hydroxyproline in wound and at the same time reduce the levels of interleukin-1 (IL-1) and tumor necrosis factor-β (TNF-β), thereby accelerating the wound healing for rats [8]
Previous studies have shown that application of Shengji ointment in patients with second-degree burns might be beneficial to improve their wound healing rate, but practice has indicated that the wound pain caused by burns can seriously affect the treatment willingness of patients, and some patients suffer from intolerable pain when changing fresh dressing, leading to poor treatment compliance [10, 11]
Summary
Burn injury is tissue damage caused by heat, which is divided into first-degree burn, superficial second-degree burn, deep second-degree burn, and third-degree burn, of which the first-degree burn only injuries the epidermis and does not damage the germinal layer, so it can be healed in 3 to 5 days without scarring the skin [1, 2]. Scholars Fang M A et al used silver sulfadiazine as a control and applied the Qingre Shengji ointment that contained rhubarb, Chinese goldthread rhizome, baical skullcap root, and other herbs to rats with second-degree burn and found that the ointment could increase the content of vascular endothelial growth factor (VEGF) and hydroxyproline in wound and at the same time reduce the levels of interleukin-1 (IL-1) and tumor necrosis factor-β (TNF-β), thereby accelerating the wound healing for rats [8]. Previous studies have shown that application of Shengji ointment in patients with second-degree burns might be beneficial to improve their wound healing rate, but practice has indicated that the wound pain caused by burns can seriously affect the treatment willingness of patients, and some patients suffer from intolerable pain when changing fresh dressing, leading to poor treatment compliance [10, 11]. To improve the effect of topical drugs, some scholars suggested treating burn patients with immersion therapy and found that such therapy can remove the outer dressings, alleviate the pain from dressing changing, and completely clean the wound surface, which can effectively prevent infections
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