Abstract
Acute stress of various types (foot shock, exposure to cold, etc.) has been shown to reduce the endogenous content of norepinephrine in the brain. On the contrary, the present study indicates that chronic stress produced by exposing rats to cold for 6 h a day for twenty days induced elevated level of endogenous catecholamines in the brain. Also, there was increase in initial accumulation of H3-norepinephrine and increase in turn-over rate of norepinephrine in the brain. It seems that repeated exposure to cold may have induced adaptive changes in physiologic system resulting in acceleration of brain norepinephrine turnover.
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