Effect of cerebrospinal fluid drainage after aneurysm clipping on hydrocephalus, cerebral vasospasm and serum IGF-1, sVCAM-1

Abstract

Objective To investigate the value of cerebrospinal fluid drainage after aneurysm clipping in patients with intracranial aneurysm complicated with subarachnoid hemorrhage. Methods 84 intracranial aneurysms patients with subarachnoid hemorrhage were selected, and they were randomly divided into study group (n=42) and control group (n=42). The control group used simple suture after aneurysm clipping, the study group was given lumbar cistern drainage by implementation of the dural suture tube after aneurysm clipping.Before and after hydrocephalus and cerebral vasospasm, treatment changes of serum insulin-like growth factor 1 (IGF-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels were compared between the two groups. Results The incidence rate of hydrocephalus of the study gruop was 4.8%, which was significantly lower than the 14.3% of the control group (χ2=9.743, P 0.05). The serum levels of IGF-1 and sVCAM-1 between the two groups had no statistically significant differences before operation (t=0.417, 0.603, all P>0.05). At the 8th day after operation, the serum levels of sVCAM-1 and IGF-1 of the study group were significantly lower than those of the control group (t=7.335, 6.856, all P<0.05). Conclusion After aneurysm clipping, the lumbar cistern drainage tube drainage is beneficial to reduce hydrocephalus and cerebral vasospasm incidence, inhibit the expression of serum IGF-1, sVCAM-1, with less adverse reactions, it is worthy of application. Key words: Aneurysm clipping; Subarachnoid hemorrhage; Cerebrospinal fluid drainage; Hydrocephalus; Cerebral vasospasm