Effect of Bushen Huoxue Huatan decoction on the blood lipid and homocysteine levels in patients with carotid artery stenosis

Abstract

Objective To investigate the effect of Bushen Huoxue Huatan decoction on blood lipid and homocysteine (Hcy) levels of patients with carotid artery stenosis. Methods 120 cases of carotid artery stenosis were selected.The different syndromes of patients were analyzed by weight coefficient, including phlegm turbidity, blood stasis, yin deficiency and qi deficiency syndrome.Phlegm traditional Chinese medicine was used to treat the patients.Serum lipids and Hcy levels before and after treatment were measured with enzyme conversion method and enzyme repeat method. Results After weight coefficient analysis, 90.0%(108/120) of patients were phlegm turbidity syndrome, 82.5%(99/120) were blood stasis, yin deficiency was 67.5%(81/120) and qi deficiency syndrome was 51.67%(62/120). Before treatment, the Hcy, TC, TG and HDL levels of patients with phlegm turbidity, blood stasis, yin deficiency and qi deficiency syndrome were increased.After treatment, the Hcy, TC, TG and HDL levels of patients with phlegm turbidity were (10.38±0.12)μmol/L, (7.23±0.91)mmol/L, (11.03±0.13)mmol/L, (7.30±0.84)mmol/L, respectively, which of patients with blood stasis were (6.39±0.22)μmol/L, (16.37±0.21)μmol/L, (6.45±0.20)mmol/L and (3.21±0.62)mmol/L, respectively, which of patients with yin deficiency were (16.37±0.21)mmol/L, (10.22±0.88)mmol/L, (15.89±0.19)mmol/L, (10.67±0.65)mmol/L, respectively, which of patients with qi deficiency were (10.25±0.14)mmol/L, (8.20±0.73)mmol/L, (9.98±0.11)mmol/L, (8.43±0.34)mmol/L, respectively.After treatment, the levels of Hcy, TC, TG and HDL were significantly improved, and the differences were statistically significant(F=46.774, 12.310, 49.486, 59.406, all P<0.05). Conclusion Bushen Huoxue Huatan decoction is effective in the treatment of carotid artery stenosis, which can significantly improve the levels of Hcy, TC, TG and HDL, and it is of great value. Key words: Carotid stenosis; Dyslipidemias; Cysteine; Phytotherapy