Abstract
Objective To explore the effect of different blood glucose monitoring frequency on blood glucose fluctuation and control in type 2 diabetes mellitus patients with intensive insulin therapy. Methods One hundred and twenty type 2 diabetes mellitus patients With intensive insulin therapy were chosen and randomly divided into three groups. The three times group received 3 times monitoring including fasting, after breakfast and bedtime, and the five times group received 5 times monitoring including fasting, after breakfast, before supper, bedtime and before dawn, and the eight times group received the 8 times monitoring including before and after every meal, bedtime and before dawn, and the changes of the hemoglobin Alc （I-IbAlc） were observed for 4 weeks before and after the treatment. Results The average levels of HbA1 c in the three groups were decreased 4 weeks after treatment in the three groups, and the difference was not statistically significant （ F = 0. 301, P 〉0.05 ）. No difference was found in the fasting blood glucose and blood glucose before supper in the three groups （ F = 1. 450, t = 1. 760 ; P 〉 0.05 ）. The levels of blood glucose after breakfast were respectively （ 8.78 ± 0.90）, （9.08 ± 0.63 ）, （7.49 ± 1.01 ） mmol/L in the three groups, and the level of blood glucose in the eight times group was better than those of the three and five times groups, and the difference was statistically significant （F = 23. 340, P 〈 0.05 ）. The levels of bedtime blood glucose were respectively （ 8.07 ± 0.59 ）, （8.32 ± 0.75）, （7.28 ± 0.54） mmol/L in the three groups, and the blood glucose fluctuatian range in the eight times group was lowest, and the difference was statistically significant （F = 32.880, P 〈 0.0.5）. The levelof blood glucose before dawn in the eight times group was （6. 68 ± 0.59 ） mmol/L, and was better than （7.75 ±0.77） mmol/L in the five times group, and the difference was statistically significant （t =4. 170, P 〈 0.01 ）. The average levels of 24 h blood glucose in the three groups were respectively （8.33 ± 1.20）, （8.26 ± 0.97）, （7.84 ± 1.15 ） mmol/L, and the blood glucose control in the eight times group was best, and the difference was statistically significant （ F = 22.36, P 〈 0.05 ）, and the detection rate of hypoglycemia was 33.3% in the small hours. Conclusions The blood glucose fluctuation range in the eight times group is minimum. The many times blood glucose monitoring in type 2 diabetic patients with intensive insulin therapy, at least 3 times daily, can reduce and prevent the incidence of hypoglycemia. Key words: Diabetes mellitus, type 2 ; Blood glucose self monitoring; Frequency ; Intensiveinsulin therapy; Blood glucose control
Published Version
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