Effect of bladder instillation of drugs on postoperative recurrence of superficial bladder cancer

Abstract

Objective To compare and analyze the Brucea javanica oil emulsion, hydroxy camptothecin bladder perfusion of recurrence after operation of superficial bladder cancer. Methods 80 cases with superficial bladder cancer were randomly divided into group A and group B(n=40). Group A received intravesical instillation of Brucea javanica oil emulsion, group B received intravesical instillation of hydroxycamptothecin.The serum tumor marker levels were compared between two groups, and the recurrence rate and adverse reactions in the two groups were observed. Results At 1 day before operation, postoperative 7d, the serum Dickkopf-1(DKK-1), Dickkopf-2(DKK-2), Dickkopf-3(DKK-3), Dickkopf-4(DKK-4), vascular endothelial growth factor A(VEGFA), vascular endothelial growth factor B(VEGFB), vascular endothelial growth factor C(VEGFC) of the two groups had no statistically significant differences (P>0.05). Postoperative 6 months, the serum levels of DKK-1, DKK-2, DKK-3, DKK-4, VEGFA, VEGFB, VEGFC in group A were (20.62±2.84)g/L, (29.15±6.32)g/L, (18.66±4.53)g/L, (32.34±6.42)g/L, (80.72±9.16)g/L, (60.43±16.73)g/L, (70.31±8.41)g/L, respectively, which were lower than those of group B [(27.42±3.76)g/L, (38.16±4.34)g/L, (30.37±5.35)g/L, (47.26±7.72)g/L, (146.31±12.44)g/L, (83.14.14.07) g/L, (91.58±7.82)g/L, respectively, t=-2.92, -2.58, -2.82, -2.41, -2.80, -2.75, -2.70, all P<0.01]. The recurrence rate of group A was 7.5%(3/40), which was significantly lower than 15.0%(6/40) of group B(6/40)(χ2=6.11, P <0.05). The incidence rate of adverse reactions of group A was 12.5%, which was significantly lower than 27.5% of the control group(χ2=5.46, P<0.05). Conclusion Compared with hydroxyl camptothecine vesical perfusion, the effect of intravesical instillation of Brucea javanica oil emulsion in preventing the postoperative recurrence of superficial bladder cancer is more significant, can effectively reduce the levels of serum tumor marker, with less adverse reactions, it is worth application and promotion. Key words: Urinary bladder neoplasms; Brucea javanica; Hydroxycamptothecin; Chemotherapy, cancer, regional perfusion; Recurrence