Abstract
Effect of Autologous and Allogeneic Platelet Rich Plasma on Viability, Proliferation and Chondrogenesis of Equine Bone Marrow Derived Mesenchymal Stromal Cells
Highlights
Joint pain due to Osteoarthritis (OA) is one of the leading causes of reduced quality of life and loss of performance in people and animals [1,2,3]
Compared to Bone Marrow Derived Mesenchymal Stromal Cells (BMSCs) treated with control media, plastic adherent cells exposed to differentiation media exhibited positive uptake of von Kossa and 7% Oil-Red-O staining to confirm osteogenic and adipogenic differentiation
Platelet rich plasma is an obtainable blood derived biological product that serves as a scaffold and a source of growth factors shown to variably sustain or enhance the cellular proliferation, migration, and biological activity of progenitor cells from various tissue sources and species [45]
Summary
Joint pain due to Osteoarthritis (OA) is one of the leading causes of reduced quality of life and loss of performance in people and animals [1,2,3]. The development of cartilage deterioration eventually leads to persistent articular pain which is often ineffectively addressed by the above mentioned therapeutics. In an attempt to seek more effective alternatives for this frustrating disease, scientists and clinicians have been exploring the use of acellular and cell based biological therapeutics to enhance the repair of damaged cartilage [9,10]. Mesenchymal Stromal Cells (MSCs), have been the subject of research inquiry because they are an obtainable, self-renewing cellular therapy for musculoskeletal repair [10,11] MSCs have been shown to display disease modifying characteristics by preventing or slowing articular cartilage destruction [12,13] and promoting articular cartilage defect repair through formation of hyaline-like reparative tissue [14,15,16]. To maximize efficiency of treatment, research efforts have been made to understand the implications of using donor allogeneic MSCs for cartilage repair strategies [17]. All reactivity concerns remain, evidence would suggest that allogeneic MSCs evoke minimal immune responses and can survive transplantation in part due to a differential expression of Major Histocompatibility Complexes (MHC) on their cell surface [18,19,20,21]
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