Topical allogeneic platelet-rich plasma treatment for a massive cutaneous lesion induced by disseminated intravascular coagulation in a toy breed dog.

Tae-Ho Chung,Jin-Ho Park,Chul Park,Namjung Kim,Dae-Seung Baek

doi:10.1186/s13620-015-0032-7

Abstract

A 2-year-old intact female miniature Pinscher weighing 1.7 kg with a body condition score of 2/5 was presented for acute vomiting, lethargy for 2 days, and large petechial skin lesions on the hip region including the tail. Acute pancreatitis was diagnosed by clinical signs, strong positive cPLI test, laboratory test and ultrasound appearance. While the clinical signs associated with acute pancreatitis had improved in 3–5 days, lesion of petechial appeared on the left hip region 7 days after the presentation, with a fast progression into a necrotic tissue along the left side hip. Allogenic platelet rich plasma (PRP) with Weibrich and Kleis method was administered to promote skin healing and regeneration. Gradual and complete improvement in the dog’s wound lesions was noted approximately 1 month after applying allogeneic topical PRP. In this case report, allogeneic PRP was applied to a large regional cutaneous defect caused by coagulopathy induced by acute pancreatitis. Topical application of PRP in this case was unique in that allogeneic PRP was used instead of autologous PRP for the first time in cutaneous soft-tissue wound management in the veterinary medical field.

Highlights

Disseminated intravascular coagulopathy (DIC) is a complex set of events that arises when there is excess intravascular coagulation causing multiple-organ microthrombosis and paradoxical bleeding including the skin [1]
Studies on dogs and cats that have evaluated the ability of allogeneic Platelet rich plasma (PRP) to heal cutaneous wound and regenerate tissue are extremely rare [5]
Conventional treatments for chronic wounds including topical steroids and antibiotics with changes of dressings and debridement sometimes do not effectively promote the woundhealing cascade as in the present case induced by DIC associated with acute pancreatitis

Summary

Introduction

Disseminated intravascular coagulopathy (DIC) is a complex set of events that arises when there is excess intravascular coagulation causing multiple-organ microthrombosis and paradoxical bleeding including the skin [1]. Platelet rich plasma (PRP) enhances wound healing and helps regenerate skin tissue [5]. This report describes a very small patient (toy breed, < 2 kg) with a large skin defect including the tail and subsequent use of topical allogeneic PRP as adjunct therapy.

Results

Conclusion