Abstract
目的 探讨阿托伐他汀对急性脑梗死患者血浆NO及血小板α颗粒膜蛋白(GMP-140)水平的影响.方法94例急性脑梗死患者随机分为治疗组(阿托伐他汀组)(48例)和对照组(46例),采用硝酸酶还原法和双抗体夹心酶联免疫吸附法分别测定治疗组和对照组治疗前及治疗4周后血浆NO及GMP-140含量,并同时按照欧洲卒中评分(ESS)标准进行评分.结果治疗后治疗组和对照组血浆NO及GMP-140水平均较治疗前明显下降(P＜0.01),且治疗组较对照组下降明显(P＜0.05);治疗组和对照组ESS分值明显高于治疗前(P＜0.01),但治疗组和对照组的ESS分值无明显差异(P＞0.05).结论阿托伐他汀能降低急性脑梗死患者血浆NO及GMP-140的水平,从而减轻缺血性脑损伤,起到保护脑组织的作用。
Published Version
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