Abstract
The present study was conducted to evaluate the effects of aspirin on body weight and some liver enzyme in rats. The study was done in Veterinary Medicine College, Baghdad University. We used seventy two male rats and randomly divided into three groups (24 in each group). Group-1 was considered as control, Group-2 animals were treated by 40 mg/kg body weight (low-dose) of asprin and the Group-3 was treated by 100 mg/kg body weight (high-dose) of aspirin. The results showed no significant difference in bodyweight gain from 0 to 10 days in all groups, while the low and high-dose asprin treated rats showed decline in bodyweight gain on day 20 and day 30 of aspirin treatment. The liver enzymes, AST and ALT, increased significantly in high-dose of aspirin treated group on day 20 and 30 while the ALP was increased on all time-points in high-dose asprin treated group.
Highlights
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) which is cheap, available and has wide applications in medical science such as anti-pyretic, analgesic, anti-inflammatory action and anti-platelet action in coronary artery disease
We showed that the administration of aspirin with low-dose and highdose for 10 days, 20 days and 30 days to rats lead to derangement of liver enzymes and interference with body weight gain
The findings of present study in which the serum levels of aspartate aminotransferase (AST), alanine aminotranseferase (ALT) and alkaline phosphatase (ALP) increased in high-dose aspirin administration for 10 days, 20 days and 30 days shows functional damage to the liver but the mechanism of acetylsalicylic acid causing this damage cannot be elucidated as liver toxicity after aspirin administration need several days to develop the symptoms according to a group of researchers [14]
Summary
Aspirin (acetylsalicylic acid [ASA]) is a nonsteroidal anti-inflammatory drug (NSAID) which is cheap, available and has wide applications in medical science such as anti-pyretic, analgesic, anti-inflammatory action and anti-platelet action in coronary artery disease. Aspirin is a safe drug in low doses but can cause adverse effects at high doses. Some of the severe adverse effects of high dose of aspirin are caused by necrosis of blood vessels [1]. Long term usage of aspirin may cause liver and renal toxicity. The lethal dose of aspirin with acute oral LD50 value is about 0.9 g/kg in rats, the aspirin poisoning in rats from lethal dose range from mild to severe presentation like hepatitis, nephritis and shock [8] and the chronic toxicity of aspirin like delirium and cardiac failure [9]. Chronic toxicity of aspirin in mice occurs at dose of 3 to 20 times the tolerated dose up to a year [10,11]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
