Chronic High Doses of Nandrolone Decanoate on Blood Cell, Lipoprotein Profile, and Liver Enzymes in Male Rats

Abstract

Background: Nandrolone decanoate (ND) is a doping agent and it is used by athletes. Objectives: This study was carried out to evaluate the chronic, high doses of ND administration on Blood cell, lipid profile, and Liver enzymes in male rats. Materials and Methods: This experiment was executed on 30 wistar- Albino male rats divided, after weighing, in control, placebo, and test groups (n = 10). Test group received 15 mg/kg intramuscular (IM) ND for duration of 8 weeks. Group placebo received the same volume of placebo although control group did not receive any agent during the trial period. At the end, animals were anes- thetized by diethyl ether, scarified, and then blood samples were collected from cervical vessels immediately. Blood cell, lipoprotein profile, and liver enzymes were measured by ordinary methods. Obtained data were analyzed by SPSS V. 15, via ANOVA and Tukey test. Results were expressed as mean SD. Statistical dierence was significantly recognized by P 0.05. Results: Results showed that AST, ALT, cell blood count, hemoglobin, hematocrite, and cholesterol values in group test were in- creased significantly compared to those of other groups; however, HDL value in this group decreased noticeably compared to con- trol and Placebo groups. Conclusions: Present study revealed that chronic high doses of ND administration alter the liver enzymes, lipid profile, and blood parameter in male rats.