Abstract
Reproductive process cannot be complete without hormone and if these hormones are not in the right proportion, then reproductive process could fail. Hormones are chemical substances produced by the endocrine gland and its physiological action is exerted on a target organ different from the secretion’s site. The aim is this study is to evaluate Effect of aqueous leave extract of D. alba ness (Thorn Apple) on gonadotropic hormones (FSH, LH) and prolactin following administration of MSG and clomid citrate in male wistar rats. The study involves 35 male wistar rats weighing between 130g to 160g. The animals were randomly selected into 7 with five animals per group. Each group received the following: group 1 10mls/kg of distil water, group 2 low dose of extract (1000mg/kg), group 3 high dose of extract(2000mg/kg), group 4 MSG 800mg/kg, group 5 clomid 50mg/kg, group 6 MSG + high dose of extract and group 7 clomid+ high dose of extract. Administration of extract was done through oral gavage for 21 days, thereafter, the animals were sacrificed on the 22nd day, and blood samples were collected for hormonal analysis. The results showed significant increase in serum levels of FSH and LH in the MSG group and decreased in FHS levels in all others treated groups when compared with control. The serum levels of FSH and LH rises when extract was co-administered with MSG. The serum levels of LH slightly increased when extract was co-administered with clomid serum levels of FSH do not increased when extract was co-administered with clomid. The statistical analysis was carried out using Statistical Package for Social Science (SPSS) version 23.
Published Version
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