Follicular-Stimulating Hormone, Luteinizing Hormone, and Prolactin Serum Level in Patients with Oral Lichen Planus in Comparison to Healthy Population.

Fatemeh Lavaee,Nazila Bazrafkan,Maryam Shahrokhi Sardo,Fateme Zarei,Takashi Saku

doi:10.1155/2021/8679505

Fatemeh Lavaee, Nazila Bazrafkan + Show 3 more

Open Access

https://doi.org/10.1155/2021/8679505

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Abstract

Materials and Methods In this cross-sectional case control study, the serum level of LH, FSH, and prolactin of 40 women with lichen planus who have been referred to Shiraz Dental Faculty, Oral and Maxillofacial Disease Department during 2018-2019 has been evaluated in comparison to 40 healthy controls. Data were analyzed by SPSS version 18. Two-way ANOVA and Mann–Whitney test were used for data analysis. Results The mean serum level of FSH and LH was significantly higher in OLP patients while this difference was not reported for prolactin. Only FSH mean serum level was significantly higher in nonmenopausal OLP patients. The distribution of prolactin and FSH hormones' serum level was in normal range. Conclusions The high serum level of FSH and LH can affect OLP pathogenesis by estrogen and progesterone modulation.

Highlights

Oral lichen planus (OLP) is an oral potentially malignant disorder, with a frequency of prevalence of 1.4% in the world
Since OLP is an autoimmune disease and there is no evaluation in literature about the relation of sexual hormone on clinical aspect of OLP presentation, in this study, we aimed to evaluate any possible relation of FSH, LH, and prolactin level and OLP
This cross-sectional case-control study was done on women with OLP who have been referred to Shiraz Dental Faculty, Oral and Maxillofacial Disease Department during 20182019

Summary

Introduction

Oral lichen planus (OLP) is an oral potentially malignant disorder, with a frequency of prevalence of 1.4% in the world. Oral lichen planus is a T cell-mediated autoimmune disease with an unknown etiology, but some evidences showed that cytotoxic CD8+ cells induce oral epithelial cell apoptosis. Cytotoxic CD8+ cells affect the keratinocytes with specific surface antigens and recognized the basal epithelial cells as foreign body which lead to basal epithelial layer degeneration [1,2,3]. OLP has slight prevalence in women during 30-60 years old [3,4,5]. There are some reports about the susceptibility of women for autoimmune diseases [6, 7]. Women are more prone for these diseases such as systemic lupus erythematous Hashimoto thyroiditis. The role of sex hormones in triggering the immune system has been shown in previous studies [6,7,8]

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