Effect of anti-tuberculosis drugs on the inflammatory factors and pulmonary function in patients with multi drug resistant tuberculosis

Abstract

Objective To investigate the effect of fiberoptic bronchoscopy on the inflammatory factors and pulmonary function in patients with multidrug-resistant tuberculosis. Methods 96 cases of multidrug-resistant tuberculosis patients were divided into intervention group and control group, each group of 48 cases.The control group according to the results of drug sensitivity test to develop personalized chemotherapy program.On the basis of the control group, the intervention group was treated with fiberoptic bronchoscopy.Two groups of sputum negative, focus absorption, cavity closure were compared.Before and after treatment, the changes of inflammatory factors and pulmonary function in the two groups were detected. Results In the observation group, the sputum negative rate, the absorption rate and the cavity closure rate were significantly higher than those in the control group.The difference was statistically significant (P 0.05). Conclusions The perfusion of anti tuberculosis drugs can significantly reduce the inflammatory response and improve pulmonary function in patients with multidrug-resistant. Key words: Fiberoptic bronchoscopy; Anti tuberculosis drugs; Multi drug resistant tuberculosis; Inflammatory factor; Lung function