Meta-analysis of the efficacy of combined interventional therapy through bronchoscope with general chemotherapy in the treatment of multidrug-resistant tuberculosis

Abstract

Objective To evaluatethe efficacy of interventional therapy through bronchoscope in the treatment of multidrug-resistant tuberculosis. Methods Searching the PubMed, EMBASE, Cochrane Library, CNKI, Wanfang database and VIP database, to collect randomized controlled trails (RCTs), which all published in the openly journals either in Chinese or English from their establishment to 30th November 2017, and involving interventional therapy through bronchoscope for multidrug-resistant pulmonary tuberculosis.After making data extraction and quality assessment, the RevMan 5.3 software was used to perform meta-analysis and evaluate the risk of bias in the study. Results There were eventually included in 3 388 cases, including 1 745 cases of interventional therapy (experimental group) and 1 643 cases of normal chemotherapy (control group). The results showed in the experimental group, there were significant differences in the rate of sputum negative conversion in the control group at 3 months and the sputum negative conversion rate, the lung lesion absorption rate and curable rate of cavity at the end of treatment were all significantly different between two groups, respectively (P<0.05). Conclusions Interventional therapy combined with chemical therapy is obviously better than chemotherapy alone.However, the quality of this evaluation is limited, and more high quality research needs to be carried out. Key words: Tuberculosis; Meta-analysis; Interventional therapy