Efficacy of percutaneous lung cavity injection of medicine for treatment of multi-drug resistant cavernous tuberculosis: a meta-analysis

Abstract

Objective To systematically review the efficacy of percutaneous lung cavity injection of medicine for treatment of multi-drug resistant cavernous tuberculosis. Methods The Pubmed、Cochranel Library、CNKI、CMB、VIP、Wanfang database were retrieved to collect the randomized controlled trial (RCT) of the efficacy of percutaneous lung cavity injection of medicine for treatment of multi-drug resistant cavernous tuberculosis, up to April 2016 sincedatabase establishment.Two reviewers in dependently screened studies according to the inclusion and exclusion criteria, extracted data and assessed quality of the included studies.Then Meta-analysis was conducted using RevMan 5.3 software. Results 15 RCT were included, involving 1 546 cases of multi-drug resistant cavernous tuberculosis.In the effectiveness, sputum negative conversion rate、cavity closure rate、lesion absorption rate with Percutaneous lung cavity injection were all higher than those in the multi-drug resistant cavernous tuberculosis control group.Percutaneous lung cavity injection of medicinefor treatment can improve the clinical effectiveness of the multi-drug resistant cavernous tuberculosis significantly. Conclusions It deserves further investigation and spreading in clinical practice. Key words: Percutaneous lung puncture; Multi-drug resistant tuberculosis; Cavity; RCT; Meta-analysis