Effect of anterior hypothalamic and mammillary area lesions on territorial aggressive behaviour in male rats

Abstract

Adult male Wezob-rats were bilaterally lesioned in either the medial anterior hypothalamic area or the mammillary bodies. The behaviour of these animals when confronted with a male intruder within their own territory, was observed and recorded before and after lesioning and compared with the behaviour of sham-operated animals. Anterior hypothalamic lesions, including large parts of the anterior hypothalamus, the rostral part of the ventromedial hypothalamic nucleus and smaller caudal parts of the preoptic area, led to strong increases in defensive behaviour. This included a decreased tendency to investigate the intruder and an exaggerated defensive reaction when approached by the intruder. Ingestive behaviour and bodyweight were enhanced. Mammillary body lesions, including large parts of the ventral and dorsal premammillary nucleus, the caudal part of the arcuate nucleus, the medial mammillary nucleus, the posterior mammillary nucleus, the supramammillary peduncle and closely surrounding areas, led to a marked increase in offensive behaviour. This was characterized by high levels of initatives and aggression towards an intruder. It is suggested that two distinct neural substrates exist in the medial hypothalamus, which normally modulate defensive (anterior medial hypothalamus) or offensive (posterior medial hypothalamus) aspects of intermale aggression.