EFFECT OF ALUMINIUM FLUORIDE ON LIVER FUNCTIONS OF RATTUSNORVEGICUS AFTER AMELIORATION BY MORINGA OLEIFERA

Abstract

Animals and humans are frequently exposed to aluminium and fluoride, and poisoning can occur. Ingestion of aluminium-fluoride occurs primarily through inhalation of aerosols or particles, food, water and medication. This study addresses the serious effects of aluminum fluoride on liver function in albino rats (SGPT, SGOT and ALP) and their amelioration by Moringa oleifera. In this study, we selected 150 healthy adult male albino rats of almost same size and weight ((120 ± 25 gm) and eight weeks old)(because they have the same physiology as humans) and divided them into three groups (control group, treated-I with ALF and treated-II (ALF + Moringa). Rats were maintained on the diet selected according to diagnosis. According to the experimental protocol, rats were exposed to aluminum fluoride and Moringa. Biochemical studies of blood were performed according to standard methods and procedures. Significant changes in liver function (SGOT, SGPT and ALP) were observed in this study. The results showed that excessive aluminum fluoride intake worsened liver function, possibly due to the toxicity of aluminum fluoride. Aluminum fluoride induced liver dysfunction is mediated by increased oxidative stress in rats. Aluminum fluoride has a negative effect on blood sugar in albino rats. However, by including moringa in the treatment of albino rat, the negative effects of fluoride are reduced due to its healing effects. Keywords: Aluminium, Fluoride, Moringa oleifera, Albino Rat, SGPT, SGOT, ALP.