Alterations in Biochemical Markers of Liver and Kidney Function and Oxidative Stress Indices on Sub-acute Exposure of Enrofloxacin in Albino Rats

Abstract

Background: The present study was performed to evaluate Alterations in biochemical markers of liver and kidney function and oxidative stress indices on sub-acute exposure of enrofloxacin in albino rats. Methods: Albino rat weighing 200-300 gm were treated with enrofloxacin orally with the help of gavage needle and devided into three groups each group consist six rats. The rats of group I were served as control. However, rats of group II and III were treated with enrofloxacin @ 5 mg/kg b.wt., enrofloxacin @ 10 mg/kg b.wt. respectively. All the groups received medication orally, once daily for 28 days and blood samples were collected on the 28 day of experiment by the help of capillary tube and processed by laboratory methods. Result: Enrofloxacin altered the functions of liver and kidney as indicated by the alteration in the biochemical markers of liver and kidney function. Enrofloxacin significantly enhanced the concentration of biochemical markers of liver function viz. ALT, AST, GGT, ALP, albumin and bilirubin as compared to control. The concentration of biochemical markers of kidney function viz. BUN and creatinine was significantly enhanced after enrofloxacin administration as compared to control. Enrofloxacin administration induced oxidative stress in rats as indicated by significant decrease in concentration of catalase, superoxide dismutase and reduced glutathione in blood as compared to control. However, lipid peroxidation was significantly enhanced as indicated by increased level of MDA in blood as compared to controlConclusion: Thus, enrofloxacin have ability to altered the biochemical markers of liver and kidney and also have potency to induced oxidative stress in albino rats after the sub-acute exposure for 28 days.