Effect of alprostadil combined with Salvia miltiorrhiza in treatment of hyperlipidemic acute pancreatitis

Abstract

Objective To investigate the effect of alprostadil combined with Salvia miltiorrhiza in treatment of hyperlipidemic acute pancreatitis. Methods Patients with high cholesterol of hyperlipidemic acute pancreatitis were randomly divided into control group and treatment group, 32 cases in each group.The control group were treated with conventional therapy combined with alprostadil 10μg intravenous injection, the treatment group was given Salvia miltiorrhiza injection 20mL vein infusion on the basis of the control group.The abdominal pain relief time, APACHE-II, C reactive protein levels, prognosis, hospitalization time and cost were compared between the two groups. Results The abdominal pain relief time, APACHE-II score, C reactive protein level in the treatment group were (5.31±1.09)d, (2.34±1.18), (48.41±22.64)mg/L, which were better than those in the control group (8.16±1.39)d, (4, 47±1.68) and (65.34±18.02)mg/L, the differences were statistically significant (t=9.08, 0.14, 5.84, -0.49, 3.31, all P 0.05). The operation rate of control group was 31.25% (10/32), which was significantly higher than that of the treatment group [6.25%(2/10)], the total hospitalization time, total cost of the treatment group were (14.50±1.55)d and (4.97±1.00)ten thousand yuan, which were significantly lower than those of the control group (16.78±1.83) d and (5.72±1.71)ten thousand yuan, the differences were statistically significant (χ2=6.65, t=1.00, t=5.39, all P<0.05). Conclusion Alprostadil combined with Salvia miltiorrhiza injection in the treatment of hyperlipidemia hyperlipidemia acute pancreatitis is safe, has good treatment effect, and can shorten the course of disease, reduce patients' hospitalization time and cost, and effectively improve the cure rate. Key words: Pancreatitis; Hyperlipidemic; Alprostadil; Salvia miltiorrhiza