Effect of advanced analgesia with parecoxib sodium on the dosage of sufentanil for postoperative analgesia in patients underwent upper abdominal surgery

Abstract

Objective To investigate the effect of piracoxib sodium on analgesia in patients with upper abdominal surgery, and to provide a reference for the choice of analgesia in these patients. Methods A total of 120 patients with abdominal surgery (stomach, liver, pancreas, spleen, etc.) were enrolled using computer random software, including 81 males and 39 females, 37-62 years old, BMI 17.6-24.2kg/m2, ASA grade I-II.They were randomly divided into parecoxib sodium group (P group) and control group (C group) using computer random software, 60 patients in each group.The two groups were treated with midazolam 0.05mg/kg, propofol 1-1.5mg/kg, rocuronium 0.6mg/kg, sufentanil 0.6μg/kg for anesthesia induction.TCI propofol 2-4mg·kg-1·h-1 and intermittent intravenous injection of sufentanil 0.1-0.2μg/kg, rocuronium 0.15-0.3mg/kg to maintain intraoperative BIS value between 40-60.The visual analogue scale (VAS) was recorded at 2h, 4h, 6h, 8h and 12h after operation.The postoperative analgesia of sufentanil and PCIA bolus times were recorded at 12 hours postoperatively.The incidence of complications such as postoperative sleepiness, skin pruritus, postoperative nausea and vomiting (PONV) and other anesthesia-related complications were recorded. Results The VAS scores of the patients in the P group [(1.41±0.29)points, (1.55±0.30)points] were significantly lower than those in the C group [(1.86±0.33)points, (1.95±0.41)points] both at static state and active state immediately out of the operation room (t=7.934, 6.099, all P<0.05). The dosage of sufentanil and the PCIA bolus times in the P group were significantly lower than those in the C group at 12 hours after operation (t=3.732, 4.205, all P<0.05). The incidence rates of lethargy, PONV and skin pruritus in the P group were significantly lower than those in the C group (χ2=8.107, 3.927, 4.227, all P<0.05). Conclusion In the patients of upper abdominal surgery, the analgesic effect of parecoxib sodium can significantly reduce the dosage of sufentanil and reduce the risk of postoperative complications at the same time, it is worthy of promotion in clinical use. Key words: Analgesia; Parecoxib sodium; Sufentanil