Abstract
Purpose: To study the effects of the combined use of Xiaochaihu decoction and teprenone on peripheral blood T lymphocytes in chronic atrophic gastritis (CAG) and gastric mucosal expression of cyclooxygenase-2 (COX-2).Methods: Patients with CAG who were treated at Traditional Chinese Medicine Hospital of Jiaxing from January 2017 to January 2018 were used as subjects. They consisted of observation and control groups (99 patients per group). Both groups were treated with teprenone (50 mg, thrice daily), but patients in the observation group received 200 mL of Xiaochaihu decoction, in addition to teprenone. The treatments were given orally, and lasted for 3 weeks. Comparisons were made between the two groups with respect to the effects of the treatments on peripheral blood T lymphocytes, CAG, and quality of life.Results: Peripheral T lymphocytes, chronic atrophic gastritis and quality of life in patients in the observation group were significantly improved, relative to control group patients. The combined treatment led to a significant decrease in the expression of COX-2. After treatment, there was upregulation in CD3+, CD4+ and CD4+/CD8+ levels in both groups, relative to the corresponding levels prior to drug exposure (p < 0.05). However, the observation group levels of CD3+, CD4+ and CD4+/CD8+ were higher than corresponding control values (t = -14.45, p < 0.001; t = -12.47, p < 0.001; t = -3.49, p < 0.001, respectively). Moreover, results from histopathological studies showed marked improvement in the observation group.Conclusion: A combination treatment of Xiaochaihu decoction and teprenone improves the condition of CAG patients via changes in peripheral blood lymphocytes and COX-2 expression in gastric mucosa.Keywords: Xiaochaihu decoction, Teprenone, Chronic atrophic gastritis, T lymphocytes, Cyclooxygenase-2
Highlights
Chronic atrophic gastritis (CAG) is caused by various factors
Gastric cancer usually develops in stages, from superficial gastritis to atrophic gastritis, and thereafter to gastric mucosal epithelial hyperplasia, to gastric mucosal intraepithelial neoplasia
The aim of this study was to investigate the influence of combination of Xiaochaihu decoction and teprenone on peripheral blood lymphocytes, as well as its effect on the expression of COX-2 in CAG patients
Summary
The typical clinical manifestations are dull pain in abdomen and a feeling of fullness or belching It is a common digestive system disease characterized by atrophy of gastric epithelial tissue and glands, attenuated mucosa, and thickening of mucosal muscle layer [1]. It is often accompanied by intestinal metaplasia, erosion, and abnormal hyperplasia. Gastric cancer usually develops in stages, from superficial gastritis to atrophic gastritis, and thereafter to gastric mucosal epithelial hyperplasia, to gastric mucosal intraepithelial neoplasia. This last stage gives rise to gastric cancer. The combination of Xiaochaihu decoction and teprenone in the treatment of CAG has yielded certain beneficial effects, the mechanism involved in this treatment is still unclear [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
