Effect observation of LEEP knife conization of cervix combined with application of recombinant interferon a-2b vaginal gel before and after surgery in patients with cervical intraepithelial neoplasias

Abstract

Objective To explore the therapeutic effect of LEEP knife conization of cervix combined with application of recombinant interferon a-2b vaginal gel before and after surgery in patients with cervical intraepithelial neoplasias (CIN). Methods 80 cases of CIN treated by LEEP knife in our hospital and Maternal and Child Health Care Hospital of Dongguan from March 2014 to December 2015 were selected, and divided into study group and control group according to the random number table. Study group was given recombinant interferon a-2b vaginal gel before and after surgery, while control group was given recombinant interferon a-2b vaginal gel after surgery. Compared the operative time, blood loss, hospital stay, efficacy of two groups. Results There was no statistically significant difference in the operative time between two groups (P>0.05); the blood loss, hospital stay in study group were less than those in control group, with statistically significant differences (P<0.05). The total effective rate in study group (95%) was significantly higher than that in control group (80%), with statistically significant difference (P<0.05). Conclusion The application of recombinant interferon a-2b vaginal gel before and after LEEP knife conization can effectively improve the clinical symptoms of CIN patients, improve surgical outcomes, with significant clinical curative effect. Key words: Cervical intraepithelial neoplasias; LEEP knife conization of cervix; Recombinant interferon a-2b vaginal gel