Effect and safety of amiodarone in emergency treatment of tachyarrhythmia

Abstract

Objective To analyze the efficacy and safety of amiodarone in the treatment of patients with tachyarrhythmia in emergency department. Methods The clinical data of 112 patients with emergency tachyarrhythmia admitted to the Emergency Department of the First People's Hospital of Jinzhong from March 2017 to March 2018 were analyzed.According to the different treatment plans applied, the patients were divided into two groups, with 56 patients in each group.The control group was given routine emergency treatment, and the observation group was treated with routine emergency treatment and amiodarone.The efficacy, blood pressure, heart rate and safety in the two groups were compared. Results The total effective rate in the observation group was 91.07%, which was higher than that in the control group(69.64%) (χ2=8.145, P<0.05). The diastolic blood pressure, systolic blood pressure and heart rate in the observation group were (77.40±6.21)mmHg, (124.24±6.15)mmHg and (130.18±6.14)beats/min, respectively, which were lower than those in the control group[(93.47±7.40)mmHg, (140.60±7.48)mmHg and (150.35±12.32)bests/min](χ2=8.145, t=12.448, 12.642, 10.966, all P<0.05). The total incidence rate of adverse reactions in the observation group was 3.57%, which was lower than 19.64% in the control group (χ2=7.049, P<0.05). Conclusion For patients with tachyarrhythmia in the emergency department, the application of amiodarone has significant curative effects and high safety, which can help stabilize their blood pressure, heart rate and improve their conditions, and yet incurs less adverse reactions.Therefore, it is of significant value to be popularized in clinical applications. Key words: Arrhythmias, cardiac; Anti-arrhythmia agents; Emergency treatment; Blood pressure; Tachyarrhythmia