Efektivitas Ekstrak Etanol Daun Kele (Brasica oleracea var. sabellica) Terhadap Kadar Malondialdehide, Profil Gula Darah, SGOT, dan SGPT Tikus (Rattus norvegicus) Jantan Yang Diinduksi Aloksan

Abstract

Diabetes Mellitus (DM) is a metabolic disease characterized by hyperglycemia due to a lack of insulin or caused by insulin resistance. The aim of this study was to determine the effectiveness of kale leaf extract on blood sugar levels, SGOT, SGPT, MDA, and rat liver histology induced by alloxan. This study used 3 months old adult rats weighing 200-300 grams. The research design used was a Completely Randomized Design (CRD) consisting of 5 treatments and for each treatment, there were 5 replications. Five treatments consisted of K- as a negative control (given 0.2 ml NaCl), K + as a positive control (given alloxan dose 120 mg / kg BW), P1 (given alloxan dose 120 mg / kg BW and kale leaf extract 250 mg / kg BW), P2 (given alloxan dose of 120 mg / kg BW and 500 mg / kg BW of kale leaf extract) and P3 (given alloxan dose of 120 mg / kg BW and kale leaf extract of 1000 mg / kg BW). The treatment given to male rats was carried out for 28 days. Furthermore, checking blood sugar levels, SGOT, SGPT, and MDA The data obtained were analyzed using the SPSS 15.0 program. The results showed that giving kale leaf ethanol extract at a dose of 1000 mg/kg BW was the most effective in reducing levels of Malondialdehyde (MDA), blood sugar levels, SGOT, SGPT, and liver in alloxan-i