Editorial

Abstract

I am very pleased to announce that the editorial team for the Journal of Pharmaceutical Sciences (JPharmSci®) has decided to dedicate a future issue of the journal to Professor Samuel H. Yalkowsky and to the science that he has loved and fostered throughout his professional career. Professor Yalkowsky is currently a Professor of Pharmaceutical Chemistry in the School of Pharmacy at the University of Arizona, Tucson, AZ. The honor of a Dedicated Issue of JPharmSci® is being bestowed on Professor Yalkowsky because of the tremendous impact that he has had and he continues to have on our understanding of the relationship between chemical structures and physicochemical properties, especially as it relates to the solubility and stability of small organic molecules. For example, Professor Yalkowsky has developed a general solubility equation, which is one of the best techniques available for estimating the solubility of small organic compounds in water. Dr. Yalkowsky has also been involved in the alteration of the solubility of small organic molecules by physical means, including the development of formulations for insoluble drugs and the improved dissolution of environmentally important solutes from the soil. His formulation work has been extended to include the development of novel dosage forms and the pharmaceutical evaluation of parenteral formulations. This Dedicated Issue will include original scientific articles (Research Articles, Notes, and Rapid Communications), Perspectives, Reviews, Minireviews, Lessons Learned, and Commentaries that highlight Professor Yalkowsky’s scientific interests including, but not limited to, the following: (i) prediction and measurement of aqueous and nonaqueous solubility; (ii) modification of aqueous solubility by the use of cosolvents, complexing agents, surfactants, prodrugs, lipids, amorphous forms, and cocrystals; (iii) enhancement of dissolution and oral bioavailability by physical and chemical modification of solubility; (iv) the evaluation of parenteral product characteristics, stability, and performance; (v) computational modeling of biological and physiochemical processes, including intestinal absorption, precipitation, crystal growth, and other phase transitions, including mesophase and polymorphic transitions; and (vi) the use of quantitative structure-activity relationships and quantitative structure-property relationships in drug discovery and drug product development. Professor Yalkowsky’s many significant contributions to these scientific areas will be summarized in a Commentary written by the guest editors and published in this Dedicated Issue of JPharmSci®. I am very pleased to announce that Professors George Zografi (University of Wisconsin), Kenneth R. Morris (Long Island University), Peter Wildfong (Duquesne University), Paul Myrdal (University of Arizona), Rodolfo Pinal (Purdue University), and Dr. Neere Jain (Syros Pharmaceuticals) have agreed to be the guest editors for the Sam Yalkowsky Dedicated Issue of JPharmSci®. The guest editors would welcome proposals for original scientific articles (Research Articles, Notes, and Rapid Communications), Reviews, Minireviews, Lessons Learned, and Commentaries in those research areas in the pharmaceutical sciences that Professor Yalkowsky has contributed to throughout his professional career. In addition, they would also welcome the perspectives of pharmaceutical scientists in the form of Commentaries about the significance of Professor Yalkowsky’s research based on their personal experiences as scientists working in academia, industry, and government. If you are interested in contributing to this dedicated issue, and thus honoring Professor Yalkowsky, please contact Professor George Zografi (gdzografi@pharmacy.wisc.edu) for more details. Finally, I anticipate that the Samuel H. Yalkowsky Dedicated Issue will be published as the January 2018 issue of JPharmSci®.