Abstract
Tako-tsubo cardiomyopathy (TCM) is an acute cardiac syndrome with severe hypokinesia of the left ventricle (LV), often affecting the apex causing apical ballooning and heart failure. Sympathetic stress is a trigger of TCM and is probably underdiagnosed and not uncommon in ICU patients [1]. We have developed an experimental rat model of TCM, in which LV apical akinesia develops after intraperitoneal (i.p.) injection of isoprenaline with many similarities to clinical TCM [2]. We recently demonstrated that pre-treatment with isoflurane could prevent the development of LV apical akinesia in this TCM animal model [3].
Highlights
Tako-tsubo cardiomyopathy (TCM) is an acute cardiac syndrome with severe hypokinesia of the left ventricle (LV), often affecting the apex causing apical ballooning and heart failure
In the present study, we examined whether isoflurane, when used for treatment, could attenuate the degree of LV dysfunction and reduce mortality in a TCM animal model
Extent of apical akinesia was expressed as percentage of LV endocardial length that was akinetic
Summary
Tako-tsubo cardiomyopathy (TCM) is an acute cardiac syndrome with severe hypokinesia of the left ventricle (LV), often affecting the apex causing apical ballooning and heart failure. Sympathetic stress is a trigger of TCM and is probably underdiagnosed and not uncommon in ICU patients [1]. We have developed an experimental rat model of TCM, in which LV apical akinesia develops after intraperitoneal (i.p.) injection of isoprenaline with many similarities to clinical TCM [2]. We recently demonstrated that pre-treatment with isoflurane could prevent the development of LV apical akinesia in this TCM animal model [3]
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