Reverse Takotsubo Stress Cardiomyopathy During Liver Transplantation

Abstract

Takotsubo cardiomyopathy (TC), also known as stress-induced cardiomyopathy or “broken heart syndrome,” is characterized by an acute, reversible ventricular wall motion abnormality.1Prasad A Lerman A Rihal CS. Apical ballooning syndrome (Tako-tsubo or stress cardiomyopathy): A mimic of acute myocardial infarction.Am Heart J. 2008; 155: 408-417Crossref PubMed Scopus (1297) Google Scholar Typical TC involves apical hypokinesis/akinesis and basal hyperkinesis, but anatomic variants have been described, including a midventricular akinesis/hypokinesis and a basal wall motion abnormality, referred to as “reverse TC” (rTC).1Prasad A Lerman A Rihal CS. Apical ballooning syndrome (Tako-tsubo or stress cardiomyopathy): A mimic of acute myocardial infarction.Am Heart J. 2008; 155: 408-417Crossref PubMed Scopus (1297) Google Scholar This is a rare form of TC that has been reported to have distinct clinical and diagnostic criteria. Takotsubo cardiomyopathy has been reported in the perioperative period of major surgeries, including orthotopic liver transplantation (OLT).2Bedanova H Ondrasek J Filipensky P et al.Inverted takotsubo cardiomyopathy as an early complication after liver transplantation.Am J Case Rep. 2021; 22e930484Crossref PubMed Scopus (3) Google Scholar, 3Eagle SS Thompson A Fong PP et al.Takotsubo cardiomyopathy and coronary vasospasm during orthotopic liver transplantation: Separate entities or common mechanism?.J Cardiothorac Vasc Anesth. 2010; 24: 629-632Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar, 4Lee HR Hurst RT Vargas HE. Transient left ventricular apical ballooning syndrome (takotsubo cardiomyopathy) following orthotopic liver transplantation.Liver transpl. 2007; 13: 1343-1345Crossref PubMed Scopus (28) Google Scholar, 5Mukhtar A Moharam H Sarhan K et al.Liver transplantation using dexmedetomidine in a patient with a history of takotsubo cardiomyopathy.A & A case reports. 2016; 6: 14-16Crossref PubMed Scopus (7) Google Scholar, 6Saner FH Plicht B Treckmann J et al.Tako-tsubo syndrome as a rare cause of cardiac failure in liver transplantation.Liver Int. 2010; 30: 159-160Crossref PubMed Scopus (21) Google Scholar, 7Tachotti Pires LJ Cardoso Curiati MN Vissoci Reiche F et al.Stress-induced cardiomyopathy (takotsubo cardiomyopathy) after liver transplantation-report of two cases.Transplant Proc. 2012; 44: 2497-2500Crossref PubMed Scopus (41) Google Scholar, 8Tiwari AK D'Attellis N Intraoperative left ventricular apical ballooning: Transient takotsubo cardiomyopathy during orthotopic liver transplantation.J Cardiothorac Vasc Anesth. 2008; 22: 442-445Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar, 9Vitin AA Pennington MW Bowdle TA et al.Stress (takotsubo) cardiomyopathy during liver transplantation: Case study and literature review.Transplant Proc. 2018; 50: 211-216Crossref PubMed Scopus (6) Google Scholar, 10Bedanova H Orban M Nemec P. Postoperative left ventricular apical ballooning: Transient takotsubo cardiomyopathy following orthotopic liver transplantation.Am J Case Rep. 2013; 14: 494-497Crossref PubMed Scopus (16) Google Scholar Timely intraoperative diagnosis of rTC via transesophageal echocardiography (TEE), in the setting of OLT, is challenging. New left ventricular dysfunction, hemodynamic changes, and an altered electrocardiogram can be potentially due to TC or its variants including rTC. The authors present a case of intraoperative rTC during OLT and detail the diagnostic and clinical management. A 57-year-old White woman with a history of cryptogenic cirrhosis, status post-OLT 25 years earlier, presented for retransplantation due to chronic rejection. She had a Model for End-Stage Liver Disease score of 35, and underwent transjugular intrahepatic portosystemic shunt 2 days prior to retransplantation. Her acute liver decompensation was complicated by mild encephalopathy, grade 2 esophageal varices requiring banding, and hepatorenal syndrome requiring hemodialysis. The past medical history was significant for hypertension and hypothyroidism. She had no known significant cardiac history and preoperative coronary angiography demonstrated nonobstructive coronary artery disease. Preoperative transthoracic echocardiography demonstrated normal left ventricular ejection fraction of 70%, with no regional wall motional abnormalities and no valvular pathology. On the day of surgery, the patient was brought to the operating room, standard American Society of Anesthesiologists monitors were placed, and the patient was induced with 2 mg of midazolam, 125 µg of fentanyl, 100 mg of propofol, and 8 mg of vecuronium. After endotracheal intubation with a single-lumen 8.0 endotracheal tube, a right radial arterial catheter was placed, and a TEE probe was inserted atraumatically. Anesthesia was maintained with sevoflurane. A 9-French introducer in the right internal jugular vein was inserted under ultrasound guidance, followed by a pulmonary artery catheter. Given this patient's retransplant status and anticipation of a complex surgery with a potentially prolonged anhepatic phase, and risks of significant blood loss, hemodynamic instability, and cardiac arrest, a venovenous bypass (VVB) was planned. An outflow cannula was placed percutaneously in the right internal jugular vein at the time of central line placement. An inflow cannula was placed by the surgical team via the right femoral vein. Portal vein cannulation was avoided due to intravascular thrombosis after transjugular intrahepatic portosystemic shunt placement. The VVB was initiated prior to hepatectomy. The circulation was supported with the use of vasoactive infusions of phenylephrine, vasopressin, and norepinephrine to maintain mean arterial pressures >65 mmHg. Immediately prior to reperfusion, the patient become acutely hypotensive and premature ventricular contractions were observed on the electrocardiogram. The TEE assessment demonstrated new severe depression of left ventricular ejection fraction of 20%, basal akinesis, and apical hyperkinesis. Additional inotropic support was implemented with intermittent boluses of epinephrine and ephedrine. Hemodynamics stabilized and portal vein reperfusion was tolerated well without further hemodynamic instability. The patient was weaned off VVB and the hepatic artery and biliary anastomoses were uneventful. The graft was reperfused within 7 hours from donor aortic cross-clamp. The intraoperative estimated blood loss was 5.3 liters, and the patient was transfused 10 units of packed red blood cells, 3 units of fresh frozen plasma, 1 pack of platelets, and 2 packs of cryoprecipitate. The patient was transferred to the intensive care unit while sedated and intubated. High-sensitivity troponin T assay peaked at 478 ng/L, and probrain natriuretic peptide was more than 50,000 pmol/L. Cardiac catheterization ruled out significant obstructive coronary artery disease, and laboratory testing was negative for viral infection. Postoperative transthoracic echocardiography (TTE) demonstrated severely reduced left ventricular ejection fraction of 13%, left ventricular dilatation, and severe mitral regurgitation. Given the clinical presentation, the patient was diagnosed with rTC. Diuretic therapy and a dobutamine infusion were initiated. Hemodynamics improved and the patient was extubated on postoperative day 2, and a follow-up TTE on postoperative day 12 demonstrated improved left ventricular function, with an ejection fraction of 43%, and resolution of mitral regurgitation. The patient was discharged home on postoperative day 25. This report described intraoperative rTC in a patient undergoing OLT. Appropriate diagnosis and prompt clinical management resulted in a favorable outcome. Intraoperative findings of acute hemodynamic changes with acutely reduced left ventricular function in a patient with no history of coronary artery disease should alert the clinician to this potential diagnosis. Takotsubo cardiomyopathy is characterized by an acute, reversible ventricular wall motion abnormality not associated with a specific coronary artery distribution.1Prasad A Lerman A Rihal CS. Apical ballooning syndrome (Tako-tsubo or stress cardiomyopathy): A mimic of acute myocardial infarction.Am Heart J. 2008; 155: 408-417Crossref PubMed Scopus (1297) Google Scholar Although the pathophysiology of TC is poorly understood, it is associated with a sympathetic drive from physiologic or emotional stress, leading to a release of catecholamines and eventual microvascular dysfunction.11Guglin M Nazif K. New onset nonischemic cardiomyopathy post liver transplantation.Heart Fail Rev. 2022; 27: 1829-1836Crossref PubMed Scopus (4) Google Scholar Takotsubo cardiomyopathy can lead to left ventricular thrombus formation, left ventricular outflow tract obstruction, and mitral regurgitation from systolic anterior movement of the anterior mitral valve leaflet. Takotsubo cardiomyopathy was previously described as a benign condition given its transient clinical course, though its reported mortality is comparable to mortality from acute coronary syndrome.1Prasad A Lerman A Rihal CS. Apical ballooning syndrome (Tako-tsubo or stress cardiomyopathy): A mimic of acute myocardial infarction.Am Heart J. 2008; 155: 408-417Crossref PubMed Scopus (1297) Google Scholar In the United States, hospitalizations with TC as a primary or secondary diagnosis have increased from 75 cases per million adults in 2007 to 259 per million in 2012, likely due to the improved understanding of this distinct entity.12Khera R Light-McGroary K Zahr F et al.Trends in hospitalization for takotsubo cardiomyopathy in the United States.Am Heart J. 2016; 172: 53-63Crossref PubMed Scopus (70) Google Scholar Typical TC involves apical hypokinesis/akinesis and basal hyperkinesis, also described as apical ballooning.1Prasad A Lerman A Rihal CS. Apical ballooning syndrome (Tako-tsubo or stress cardiomyopathy): A mimic of acute myocardial infarction.Am Heart J. 2008; 155: 408-417Crossref PubMed Scopus (1297) Google Scholar It was first reported in 1990 and named takotsubo, which is the term for “octopus trap” in Japanese, due to the distinct appearance of the ventricle. Reverse TC is the most common variant of TC, presenting with basal akinesis and apical hyperkinesis (Table 1).13Awad HH McNeal AR Goyal H. Reverse takotsubo cardiomyopathy: A comprehensive review.Ann Transl Med. 2018; 6: 460Crossref PubMed Google Scholar Wall motion abnormalities are transient, with rapid recovery in most patients; however, acute pulmonary edema and profound circulatory collapse have been reported. Intraoperative recognition of TC and rTC depends on a high degree of clinical suspicion and availability of TEE for timely evaluation and management. This cardiac complication may go unrecognized in OLT if TEE monitoring is not adopted or if there is a lack of familiarity with atypical forms of TC. Orthotopic liver transplantation is associated with large fluid shifts, hemodynamic perturbations, increased systemic inflammatory markers, and risk of intraoperative cardiac arrest.14Bezinover D Mukhtar A Wagener G et al.Hemodynamic instability during liver transplantation in patients with end-stage liver disease: A consensus document from ILTS, LICAGE, and SATA.Transplantation. 2021; 105: 2184-2200Crossref PubMed Scopus (7) Google Scholar,15Smith NK Zerillo J Kim SJ et al.Intraoperative cardiac arrest during adult liver transplantation: Incidence and risk factor analysis from 7 academic centers in the United States.Anesth Analg. 2021; 132: 130-139Crossref PubMed Scopus (11) Google Scholar Intraoperative TEE is used in some centers to understand cardiac function and volume status during OLT. Routine use of TEE is controversial in OLT, as patients often present with esophageal varices, coagulopathy, and thrombocytopenia, thus increasing the risk of an adverse event (eg, esophageal injury, variceal tear, bleeding) with probe insertion. Additionally, the majority of patients have normal preoperative left ventricular function and invasive hemodynamic monitoring is standard. National societies, such as The American Society of Anesthesiologists, Society of Cardiovascular Anesthesiologists, and the American Society of Echocardiography, support the use of TEE in OLT for monitoring ventricular and valvular function.16Shanewise JS Cheung AT Aronson S et al.ASE/SCA guidelines for performing a comprehensive intraoperative multiplane transesophageal echocardiography examination: Recommendations of the American Society of Echocardiography Council for Intraoperative Echocardiography and the Society of Cardiovascular Anesthesiologists Task Force for Certification in Perioperative Transesophageal Echocardiography.J Am Soc Echocardiogr. 1999; 12: 884-900Abstract Full Text Full Text PDF PubMed Scopus (304) Google Scholar One of the first reports of the use of TEE in OLT was in 1992, in which the authors assessed the suprahepatic inferior vena cava anastomosis.17Bjerke RJ Mieles LA Borsky BJ et al.The use of transesophageal ultrasonography for the diagnosis of inferior vena caval outflow obstruction during liver transplantation.Transplantation. 1992; 54: 939-941Crossref PubMed Scopus (13) Google Scholar In contemporary practice, TTE is used frequently during OLT. Survey data from high volume liver transplantation centers in the United States reported frequency of intraoperative TEE use in OLT of 87%.18Wax DB Torres A Scher C et al.Transesophageal echocardiography utilization in high-volume liver transplantation centers in the United States.J Cardiothorac Vasc Anesth. 2008; 22: 811-813Abstract Full Text Full Text PDF PubMed Scopus (64) Google Scholar A recent position paper by the Society for Advancement of Transplant Anesthesia (SATA) states that the use of TEE during OLT is “an effective form of monitoring with a safety profile similar to cardiac surgery patients,” and that “it can improve outcomes in rare, but life-threatening conditions.”19De Marchi L Wang CJ Skubas NJ et al.Safety and benefit of transesophageal echocardiography in liver transplant surgery: A position paper from the Society for the Advancement of Transplant Anesthesia (SATA).Liver transpl. 2020; 26: 1019-1029Crossref PubMed Scopus (23) Google Scholar Currently, there are no standards for training and certification of liver transplant anesthesiologists performing intraoperative TEE. SATA recommends that “all anesthesiologists who use TEE during liver transplant surgery complete formal training pathways that lead to certification by the National Board of Echocardiography;” whereas other authors have proposed that a learning model based on TEE simulation may be more feasible and still enhance the acquisition of TEE skills in liver transplant anesthesiologists.20Christensen JM Nelson JA Klompas AM et al.The success of a simulation-based transesophageal echocardiography course for liver transplant anesthesiologists.J Educ Perioper Med. 2021; 23: E672PubMed Google Scholar At any rate, it is evident that the use of TEE during OLT is being adopted by liver transplant anesthesiologists.Table 1Characteristics of Takotsubo Cardiomyopathy and Reverse Takotsubo Cardiomyopathy13Awad HH McNeal AR Goyal H. Reverse takotsubo cardiomyopathy: A comprehensive review.Ann Transl Med. 2018; 6: 460Crossref PubMed Google ScholarTakotsubo CardiomyopathyReverse Takotsubo CardiomyopathyProportion of all Takotsubo cases77-99%1-23%Echocardiographic FindingsTransient hypokinesis/akinesis/dyskinesis LV apical segment, basal hyperkinesisLower LVEF than rTCTransient hypokinesis/akinesis/dyskinesis LV basal segments, apical hyperkinesisLow LVEF, but tend to be higher than TCClinical CharacteristicsOlder ageLess neurologic diseaseAcute psychiatric episodeChest pain, dyspnea, syncope, nausea, abdominal pain, diaphoresis, indigestionYounger ageMore neurologic disease (intracranial hemorrhage, multiple sclerosis)Administration of exogenous catecholaminesChest pain, dyspnea, syncope, nausea, abdominal pain, diaphoresis, indigestionMore likely complicated by pulmonary edema/cardiogenic shockDiagnostic FindingsAbsence of obstructive coronary disease on CT or angiographyElectrocardiogram changes (ST elevation and/or T-wave inversion), atrial fibrillationElevation in cardiac troponinHigher levels of BNP and CRP than rTCAbsence of obstructive coronary disease on CT or angiographyElectrocardiogram changes (ST depression and/or T-wave inversion), new bundle-branch block, prolonged QT intervalElevation in cardiac troponinProposed Pathophysiologic MechanismsSympathetic stimulation/catecholamine surgeUnlikely due to coronary artery spasmEstrogen deficiencySympathetic stimulation/catecholamine surgeCoronary artery spasmCoronary microvascular impairmentEstrogen deficiencyManagementSupportivePharmacologic/hemodynamic supportIABPMagnesium sulfateSupportivePharmacologic/hemodynamic supportBeta blockers for dynamic LV outflow tract obstructionIABPMagnesium sulfateAbbreviations: BNP, B-type natriuetic peptide; CRP, C-reactive protein; CT, computed tomography; IABP, intraaortic balloon pump; LV, left ventricle; LVEF, left ventricular ejection fraction; rTC, reverse takotsubo cardiomyopathy; TC, takotsubo cardiomyopathy. Open table in a new tab Abbreviations: BNP, B-type natriuetic peptide; CRP, C-reactive protein; CT, computed tomography; IABP, intraaortic balloon pump; LV, left ventricle; LVEF, left ventricular ejection fraction; rTC, reverse takotsubo cardiomyopathy; TC, takotsubo cardiomyopathy. In a recent national database study of 38,740 patients undergoing OLT from 2015 to 2020, the incidence of TC was higher in OLT recipients (0.3%) versus the general population (0.04%).21Zmaili M Alzubi J Alkhayyat M et al.Takotsubo cardiomyopathy in orthotopic liver transplant recipients: A cohort study using multi-center pooled electronic health record data.World J Hepatol. 2022; 14: 400-410Crossref PubMed Scopus (2) Google Scholar In another comprehensive analysis of individual cases reports of TC, 9% of >90 perioperative cases occurred in patients undergoing OLT.22Vitin AA Azamfirei L Tomescu D. Perioperative stress-induced (takotsubo) cardiomyopathy in liver transplant recipients.J Crit Care Med (Targu Mures). 2018; 4: 56-63Crossref PubMed Google Scholar Of these, there are very few reports in the literature of intraoperative TC in OLT diagnosed via TEE (Table 2), the majority of described cases occurred postoperatively. Of intraoperative reports, all authors reported normal preoperative echocardiographic findings with no obstructive coronary disease (Table 2).3Eagle SS Thompson A Fong PP et al.Takotsubo cardiomyopathy and coronary vasospasm during orthotopic liver transplantation: Separate entities or common mechanism?.J Cardiothorac Vasc Anesth. 2010; 24: 629-632Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar,5Mukhtar A Moharam H Sarhan K et al.Liver transplantation using dexmedetomidine in a patient with a history of takotsubo cardiomyopathy.A & A case reports. 2016; 6: 14-16Crossref PubMed Scopus (7) Google Scholar,8Tiwari AK D'Attellis N Intraoperative left ventricular apical ballooning: Transient takotsubo cardiomyopathy during orthotopic liver transplantation.J Cardiothorac Vasc Anesth. 2008; 22: 442-445Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar,9Vitin AA Pennington MW Bowdle TA et al.Stress (takotsubo) cardiomyopathy during liver transplantation: Case study and literature review.Transplant Proc. 2018; 50: 211-216Crossref PubMed Scopus (6) Google Scholar,23Elapavaluru S Gologorsky A Thai N et al.Perioperative stress cardiomyopathy in simultaneous liver and kidney transplantation: A call for early consideration of mechanical circulatory support.J Cardiothorac Vasc Anesth. 2017; 31: 248-253Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar TC was associated with substantial hemodynamic derangements, with some necessitating use of an intraaortic balloon pump and cardiopulmonary resuscitation.3Eagle SS Thompson A Fong PP et al.Takotsubo cardiomyopathy and coronary vasospasm during orthotopic liver transplantation: Separate entities or common mechanism?.J Cardiothorac Vasc Anesth. 2010; 24: 629-632Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar,8Tiwari AK D'Attellis N Intraoperative left ventricular apical ballooning: Transient takotsubo cardiomyopathy during orthotopic liver transplantation.J Cardiothorac Vasc Anesth. 2008; 22: 442-445Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar,9Vitin AA Pennington MW Bowdle TA et al.Stress (takotsubo) cardiomyopathy during liver transplantation: Case study and literature review.Transplant Proc. 2018; 50: 211-216Crossref PubMed Scopus (6) Google Scholar Tiwari, Eagle, and Mukhtar described decisions to abort the case to further stabilize the patient prior to transplantation, 2 patients prior to biliary anastomosis, and 1 patient prior to skin incision, with the authors further describing subsequent successful OLT in all 3 patients.3Eagle SS Thompson A Fong PP et al.Takotsubo cardiomyopathy and coronary vasospasm during orthotopic liver transplantation: Separate entities or common mechanism?.J Cardiothorac Vasc Anesth. 2010; 24: 629-632Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar,5Mukhtar A Moharam H Sarhan K et al.Liver transplantation using dexmedetomidine in a patient with a history of takotsubo cardiomyopathy.A & A case reports. 2016; 6: 14-16Crossref PubMed Scopus (7) Google Scholar,8Tiwari AK D'Attellis N Intraoperative left ventricular apical ballooning: Transient takotsubo cardiomyopathy during orthotopic liver transplantation.J Cardiothorac Vasc Anesth. 2008; 22: 442-445Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar Mukhtar et al. also noted use of dexmedetomidine infusion in the subsequent OLT, started prior to induction of anesthesia, with continued use throughout the case.5Mukhtar A Moharam H Sarhan K et al.Liver transplantation using dexmedetomidine in a patient with a history of takotsubo cardiomyopathy.A & A case reports. 2016; 6: 14-16Crossref PubMed Scopus (7) Google Scholar Dexmedetomidine was used to blunt sympathetic tone, and the surgery was successful without incident.Table 2Case Reports of Takotsubo Cardiomyopathy during Orthotopic Liver TransplantationAuthorSex/AgePhase of Surgery TC DetectedPresentationEchocardiographic FindingsIntraoperative ManagementPerioperative CourseCommentsTiwari8Tiwari AK D'Attellis N Intraoperative left ventricular apical ballooning: Transient takotsubo cardiomyopathy during orthotopic liver transplantation.J Cardiothorac Vasc Anesth. 2008; 22: 442-445Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar2008F/45Post- reperfusionHypotension, peaked T waves, VT, asystoleTypical TC,TEE placed after hemodynamic instabilityProlonged CPR,IABP,Epinephrine, vasopressin, dobutamine, dopamine, amiodaroneOLT aborted prior to biliary anastomosis.POD 5: IABP discontinuedPOD12: EF 60%VVB in placePOD 2: successful completion OLTEventual death due to hemorrhageEagle3Eagle SS Thompson A Fong PP et al.Takotsubo cardiomyopathy and coronary vasospasm during orthotopic liver transplantation: Separate entities or common mechanism?.J Cardiothorac Vasc Anesth. 2010; 24: 629-632Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar2010M/64Post-reperfusionHypotension, VT, bradycardia, ST segment elevationTypical TC,TEE placed after hemodynamic instabilitySevere hypokinesisCPR,Vasopressin, norepinephrine, cardioversion,Transvenous pacingOLT aborted prior to biliary anastomosis.Cardiac catheterization: severe RCA vasospasm.No VVBPOD 1: successful completion OLTSurvived to dischargeMukhtar5Mukhtar A Moharam H Sarhan K et al.Liver transplantation using dexmedetomidine in a patient with a history of takotsubo cardiomyopathy.A & A case reports. 2016; 6: 14-16Crossref PubMed Scopus (7) Google Scholar2016M/48After induction before skin incisionHypotension, VTTypical TC,TTE placed after hemodynamic instabilityEF 15%NorepinephrineOLT abortedNo VVBSuccessful OLT 40 days later with dexmedetomidineElapavaluru23Elapavaluru S Gologorsky A Thai N et al.Perioperative stress cardiomyopathy in simultaneous liver and kidney transplantation: A call for early consideration of mechanical circulatory support.J Cardiothorac Vasc Anesth. 2017; 31: 248-253Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar2017F/70AnhepaticPVCTypical TC,EF 25%TEE placed after inductionmitral regurgitationVasopressin, norepinephrineStable through graft reperfusionIABP in ICUPOD 15: tracheostomyVVB in placeProlonged hospital coursePOD 38: survived to dischargePOD 60: EF 50%Vitin9Vitin AA Pennington MW Bowdle TA et al.Stress (takotsubo) cardiomyopathy during liver transplantation: Case study and literature review.Transplant Proc. 2018; 50: 211-216Crossref PubMed Scopus (6) Google Scholar2018M/65AnhepaticVT, VF, bradycardiaTypical TC,Severe LV dysfunctionTEE placed after hemodynamic instabilityCPR,Cardioversion,Vasopressin, norepinephrinePOD 18: normal EFVVB was started after CPRSurvived to dischargeAbbreviations: CPR, cardiopulmonary resuscitation; EF, ejection fraction; IABP, intraaortic balloon pump; ICU, intensive care unit; LV, left ventricle; OLT, orthotopic liver transplantation; POD, postoperative day; PVC, premature ventricular contraction; RCA, right coronary artery; TC, takotsubo cardiomyopathy; TEE, transesophageal echocardiography, VF, ventricular fibrillation; VT, ventricular tachycardia; VVB, venovenous bypass. Open table in a new tab Abbreviations: CPR, cardiopulmonary resuscitation; EF, ejection fraction; IABP, intraaortic balloon pump; ICU, intensive care unit; LV, left ventricle; OLT, orthotopic liver transplantation; POD, postoperative day; PVC, premature ventricular contraction; RCA, right coronary artery; TC, takotsubo cardiomyopathy; TEE, transesophageal echocardiography, VF, ventricular fibrillation; VT, ventricular tachycardia; VVB, venovenous bypass. No cases of intraoperative rTC in OLT have been described, and there are several key findings the authors would like to share. Invasive monitoring tools (ie, arterial line, pulmonary artery catheter, central venous catheter) cannot replace intraoperative TEE for assessing cardiac function at points of substantial hemodynamic instability. There is no other definitive intraoperative method of diagnosing TC or atypical TC. There are several variants of TC, and liver transplant clinicians should be aware of the atypical variety, particularly rTC. Clinical management consists of supportive measures, with escalation of care from pharmacologic to mechanical support. The VVB can be implemented at any point to maintain venous return and provide hemodynamic support, particularly if the consensus plan is to continue with the transplant surgery. Although the liver transplant community seems uncertain about the overall value and indications of VVB, it is a powerful tool in supporting hemodynamics in patients with compromised cardiac function.24Rangrass G Vannucci A. Veno-venous bypass in liver transplantation: A commonly used technique with elusive outcome benefits.Minerva anestesiologica. 2022; 88: 538-540Crossref PubMed Scopus (1) Google Scholar The literature does not support the use of any specific prophylactic agents, such as beta-blockers or dexmedetomidine, to prevent TC. Pharmacotherapy to decrease sympathetic stimulation should be given in the context of hemodynamic goals. None. Reverse Takotsubo Cardiomyopathy During Liver Transplantation: Expert CommentaryJournal of Cardiothoracic and Vascular AnesthesiaVol. 37Issue 4PreviewTAKOTSUBO CARDIOMYOPATHY (TC), otherwise known as “broken-heart syndrome,” is a condition of which most anesthesiologists are aware; however, the Case Conference by Vannucci et al.1 points to a variation that is less familiar. Reverse Takotsubo cardiomyopathy (rTC) differs from traditional TC in that hypokinesis and/or akinesis is observed in the basilar portion of the left ventricle (LV) in contrast to the apical hypokinesis seen in the traditional form. In this case report, a patient with no prior cardiac history became acutely hypotensive and had severe depression of her LV function just prior to reperfusion during liver transplantation. Full-Text PDF Reverse Takotsubo Stress Cardiomyopathy During Liver TransplantationJournal of Cardiothoracic and Vascular AnesthesiaVol. 37Issue 4PreviewThe Case Conference by Vannucci et al. described an interesting case of reverse Takotsubo cardiomyopathy (rTC) during orthotopic liver transplantation (OLT) and the authors should be congratulated for successfully managing such a challenging case.1 Full-Text PDF