Midventricular variant of transient apical ballooning: a likely demonstration of its pathophysiologic mechanism.

Abstract

To the Editor: Transient apical ballooning (TAB) probably comprises a spectrum of transient ventricular dysfunctional patterns that lead to typical apical ballooning or midventricular, basal, or biventricular dyskinesia.1Abe Y Kondo M Matsuoka R Araki M Dohyama K Tanio H Assessment of clinical features in transient left ventricular apical ballooning.J Am Coll Cardiol. 2003; 41: 737-742Abstract Full Text Full Text PDF PubMed Scopus (541) Google Scholar, 2Bybee KA Kara T Prasad A et al.Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction.Ann Intern Med. 2004; 141: 858-865Crossref PubMed Scopus (1224) Google Scholar, 3Wittstein IS Thiemann DR Lima JA et al.Neurohumoral features of myocardial stunning due to sudden emotional stress.N Engl J Med. 2005; 352: 539-548Crossref PubMed Scopus (2373) Google Scholar, 4Kurowski V Kaiser A von Hof K et al.Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis.Chest. 2007 Sep; 132 (Epub 2007 Jun 15.): 809-816Crossref PubMed Scopus (433) Google Scholar Herein, I introduce a theory regarding the pathophysiologic mechanism of the midcavity variant on the basis of a recent case. A 71-year-old African American woman was admitted to a hospital elsewhere because of severe chest pain. Coronary angiography revealed mild atherosclerotic plaques. Ventriculography showed akinesia of the mid left ventricle, with well-preserved apical contractility (Video 1). Carvedilol and losartan were prescribed for hypertension. While continuing to have episodes of resting chest pain relieved by nitroglycerin, the patient came to our hospital for endoscopic evaluation of severe abdominal pain and chest pain with ST-T changes. Echocardiography (Video 2) revealed recurrent mid left ventricular (LV) akinesia, with preserved apical wall motion (ejection fraction, 30%). Troponin levels peaked at 1.5 ng/mL (to convert to μg/L [SI unit], multiply by 1.0). Chest pain quickly diminished after sublingual nitroglycerin. Two days later, repeated heart catheterization showed near-normal LV function (ejection fraction, 60%) and no coronary obstruction. Infusion of intracoronary acetylcholine (50 μg for 2 minutes) to detect endothelial dysfunction produced severe chest pain, T-wave changes, and diffuse narrowing of the diagonal, ramus medianus, and 2 marginal branches (Figure, left), with a Thrombolysis in Myocardial Infarction (TIMI) 0 flow pattern. The left anterior descending artery had TIMI-2 flow (Figure, left). Intracoronary nitroglycerin, 100 μg, promptly resolved these changes (Figure, right). Five minutes later, intracoronary acetylcholine (50 μg) was administered, with continuous echocardiographic monitoring. This infusion reproduced chest pain, electrocardiographic changes, and ventricular dysfunction of midcavity TAB (Video 3, clips 1 and 2). After repeated intracoronary nitroglycerin administration, these changes resolved in less than 30 seconds (Video 3, clip 3). Three days after her condition stabilized, the patient was discharged home with a treatment regimen of extended-release diltiazem (240 mg), nitrates, and L-arginine (1000 mg every 8 hours). At 6-month follow-up examination, she was symptom free; electrocardiography and LV contractility were normal. Previously, in a small pilot study involving typical TAB,5Angelini P Transient left ventricular apical ballooning: a unifying pathophysiologic theory at the edge of Prinzmetal angina.Catheter Cardiovasc Interv. 2008; 71: 342-352Crossref PubMed Scopus (73) Google Scholar I found that acetylcholine stimulation produced severe spasm of all coronay branches. I suggest that the midcavity variant results from similar intense, spontaneous spasticity that affects the diagonal, ramus, and circumflex branches and to a much lesser extent the left anterior descending artery. The patient's dominant circumflex pattern may have been important in causing the inferior/mid LV contractile changes. Indeed, TAB involving any distribution seems to feature severe coronary reactivity to acetylcholine testing, characterized by sustained, diffuse spasticity that can induce myocardial stunning, unlike short-lived spontaneous spasm in Prinzmetal angina.5Angelini P Transient left ventricular apical ballooning: a unifying pathophysiologic theory at the edge of Prinzmetal angina.Catheter Cardiovasc Interv. 2008; 71: 342-352Crossref PubMed Scopus (73) Google Scholar Intracoronary nitroglycerin can quicklyresolve such episodes.5Angelini P Transient left ventricular apical ballooning: a unifying pathophysiologic theory at the edge of Prinzmetal angina.Catheter Cardiovasc Interv. 2008; 71: 342-352Crossref PubMed Scopus (73) Google Scholar This degree of spasticity is unlike that seen in common coronary endothelial dysfunction. TAB variants seem to involve selective, not generalized, endothelial dysfunction. The current case provides important evidence (although not final proof) that in any form of TAB, early echocardiographic LV monitoring can document acetylcholine-related reproduction of contractile dysfunction and its normalization after intracoronary nitroglycerin infusion.5Angelini P Transient left ventricular apical ballooning: a unifying pathophysiologic theory at the edge of Prinzmetal angina.Catheter Cardiovasc Interv. 2008; 71: 342-352Crossref PubMed Scopus (73) Google Scholar This case supports my general theory regarding TAB5Angelini P Transient left ventricular apical ballooning: a unifying pathophysiologic theory at the edge of Prinzmetal angina.Catheter Cardiovasc Interv. 2008; 71: 342-352Crossref PubMed Scopus (73) Google Scholar while explaining the midcavity variant. Generally, TAB seems to involve a spectrum of varying clinical patterns that depend on precipitating factors (which could be overwhelming in the presence of relatively “normal” endothelial function) and baseline endothelial dysfunction (which, when generalized, would be associated with recurrent apical TAB, but, when selective, would lead to atypical TAB variants). Files in this Data Supplement: Download .mpg (1.84 MB) Help with mpg files video1 Download .mpg (1.24 MB) Help with mpg files video2 Download .mpg (1.5 MB) Help with mpg files video3 Download .mpg (1.65 MB) Help with mpg files video3 Download .mpg (1.52 MB) Help with mpg files video3