Early changes of IL -6 and IL-8 in premature infants and their relationship with prognosis

Abstract

Objective To investigate the changes of serum IL-6 and IL-8 and CRP the relationship between the expression and prognosis in premature infants. Methods The birth gestational age less than or equal to 34 weeks premature after birth respectively after admission was (< 24 hours) and admission and on the seventh day the blood samples were taken for measurement of serum IL-6 and IL-8 and CRP levels, all infants were in admission after 3-7 days of cranial ultrasound examination; corrected gestational age 40 weeks of neonatal behavioral neurological capacity determination (NBNA) and cranial MRI+DWI scanning; corrected age 1 year old seasonal movement development index (PDI) and intelligent development index (MDI) assessment. PDI and MDI suspicious / abnormal column into a group A(n=11), normal were classified as group B (n = 15) and retrospective analysis in the early neonatal IL-6, IL-8 and CRP levels. Results The levels of IL-6 and IL-8 in the two groups were statistically different, the A group was higher than that in B group, while the two groups had no significant difference between the two groups. The NBNA group had statistically significant difference between the 40 groups, while the MRI group was lower than that in A group, and the difference between the two groups was not statistically significant.. Conclusion The levels of and IL-6 were significantly increased in the early stage of IL-8 and PDI, which was related to the decrease of and MDI. Key words: Interleukin (IL); Premature infant; Prognosis