Early and Late Effects of Percutaneous Nephrolithotomy on Renal Functions According to Basal Renal Function Reserv

Abstract

Objective: In this study, we aimed to investigate the early and late effect of percutaneous nephrolithotomy on renal function based on preoperative glomerular filtration rate levels. Material and Method: Between January 2012 and November 2016, 351 patients who underwent percutaneous nephrolithotomy were included. According to the preoperative glomerular filtration rate, patients were divided into three groups: group 1 was consists of glomerular filtration rate >90 levels; group 2 was consists of glomerular filtration rate levels between 60-90; group 3 was consists of glomerular filtration rate <60 levels. Glomerular filtration rate measure¬ments were performed preoperatively, at post-operative 1st day and 3rd month. Results: On postoperative 1st day, mean glomerular filtration rate was significantly decreased in group 1 and group 2, non-significantly decreased in group 3. At 3rd month, the mean glomerular filtration rate was again decreased compared to preoperative levels in group 1 and group 2 but this time it was statistically non-significant. However, mean glomerular filtration rate of group 3 was statistically significantly increased compared to preoperative levels. Conclusions: Estimated glomerular filtration rate, as a better indicator of renal function, is significantly affected by the percutaneous nephrolithotomy procedure. Although, firstly renal function decreased after percutaneous nephrolithotomy because of the renal trauma procedure, kidney function is better at postoperative 3rd month because of the disappearance of kidney stone . So percutaneous nephrolithotomy was significantly improved the renal functions in patients with preoperative glomerular filtration rate < 60 due to renal stone.