Abstract
The endogenous opioid peptides (EOPs) are important regulators of GnRH pulse frequency. Recent evidence in sheep indicates dynorphin EOP neurons play a major role in the control of GnRH pulse frequency through direct synaptic input to GnRH cells (Goodman et al., Endocrinol., 2003). Dynorphin input to GnRH neurons has not been examined in humans. The goal of this study was to determine if dynorphin terminals directly contact GnRH neurons in the human brain.
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