Dynamics of some indicators of metabolism and non-specific immunity of calves with enterocolitis

Abstract

Intestinal diseases of newborn calves, including enterocolitis, are the most common diseases of the digestive system of young cattle. Diseases, as a rule, develop from the first days of life of animals. The aim of the work was to study the dynamics of some indicators of the humoral immunity of newborn calves, as well as to assess the state of metabolism, taking into account the inclusion of probiotics and lipoic acid preparations in the treatment regimen for animals with enterocolitis. Sick animals of the first group (experimental I), in addition to the treatment provided for on the farm (diet therapy and antibiotic therapy), before feeding were asked inside 100 ml of probiotic starter culture based on the Enterococcus faecium L3 strain; to regulate lipid metabolism, a 0.5% solution of lipoic acid was administered intramuscularly at a dose of 2 ml once a day for 10 days. Sick animals of the second group (experimental II) were treated according to the scheme used in the farm. In calves of the I experimental group, in comparison with the animals of the II group, a significantly higher level of glucose, triglycerides and total protein in the blood was established. The amount of cholesterol was slightly higher compared to the initial level, but significantly lower than in the animals of the second experimental group. As a result of immunological studies, it was found that the indicators of nonspecific protection in sick calves of I and II experimental groups at 1-2 days of age had no significant differences. However, at the age of 10 days in calves, the studied parameters differed from each other BASK in the II experimental group was 42.7 ± 2.0% lysis, in animals of the I experimental group -50.4 ± 2.3% lysis (P <0.01), activity of beta-lysines 30.7±1.9%-lysis and 51.1±4.9%-lysis, respectively (P<0.01). Lysozyme activity of blood serum in calves of II and I experimental groups did not differ (P>0.05), and was at the level of 5.0±0.5%lysis and 5.2±0.9%-lysis, respectively. In the course of the studies, a positive effect of a probiotic based on the strain of microorganisms Enterococcus faecium L3 and 0.5% lipoic acid solution was established.