Leukocyte indexes for liver lipidosis in cats

Abstract

Chronic liver failure is characterized by significant impairment of liver function due to exposure to a damaging factor for a long time. In cats, one of the most common liver diseases is lipidosis, or fatty liver dystrophy – a condition in which there is an excessive accumulation of fats in hepatocytes caused by a complex of metabolic disorders (for example, obesity, impaired energy metabolism). Diagnosis and prognosis of the course of liver diseases in cats can cause difficulties due to a number of factors, therefore, it is relevant to search and evaluate available and minimally invasive diagnostic methods for early detection and treatment strategy planning. Leukocyte indices can be one of these mechanisms. They can be useful in the diagnosis of liver diseases, as they reflect the degree of neuro-humoral reactivity and the body's response to various stimuli, in particular, to a decrease in detoxification function of the liver. The purpose of the presented study was to evaluate and compare the indicators of leukocyte indices in cats with chronic degenerative liver disease using the example of liver lipidosis with the corresponding indicators of clinically healthy animals. significant deviations of leukocyte indices associated with the level of lymphocytes and neutrophils were revealed, which allow a comprehensive assessment of leukogram parameters. The introduction and use of these indicators in veterinary practice will make it possible to better predict the course of the disease and better develop a treatment strategy. It should be noted that in order to more accurately determine the diagnostic significance and the possibility of determining forecasts, it is necessary to increase the number of animal samples with an assessment of indicators in dynamics.