Abstract

 
 
 
 The aim of this study was to examine the morphometric parameters of the thickness of the epithelial plate of the gingival mucosa, the height of the connective tissue papillae and the diameter of the lumen of hemomicrovascular white rats in the dynamics after eight, ten and twelve weeks of chronic opioid exposure. Experimental studies were performed on white male rats of reproductive age. For twelve weeks, rats were injected intramuscularly with the opioid analgesic nalbuphine at increasing average therapeutic doses of 0.212 to 0.3 mg/kg body weight. Fragments of rat jaws were used for histological and morphometric studies. Based on the analysis of the obtained morphometric parameters of the studied components of the gums, it was found that in the late stages of chronic opioid exposure there was a significant decrease in epithelial thickness and connective tissue papillae and a significant increase in the lumen diameter of hemomicrocirculatory progression of inflammatory-dystrophic changes in periodontal tissues.
 
 
 
Highlights
R of the lumen of white blood vessels in eight dynamics after eight, ten and twelve weeks of chronic opioid exposure
The second group consisted of animals that were injected daily for eight weeks with the intramuscular opioid analgesic nalbuphine in terms of rats
The thickness of the epithelium of the free gingival margin decreased on 5,96 μm and its average value was 118,74 ± 27,72 μm, and the thickness of the sulcular epithelium decreased on 5,10 μm, which was 52,14 ± 10,97 μm (p
Summary
This work is licensed under a Creative Commons Attribution 4.0 International License. Fik V. B., PhD in Anatomy, Assoc. Professor, Department of Normal Anatomy, Danylo Halytskyy Lviv National Medical University, Lviv, Ministry of Health of Ukraine, ORCID ID: https://orcid.org/0000-0002-2284-4488 KEYWORDS gingival components, rats, opioid analgesic, morphometric study.
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