Abstract
The aim of the study was to investigate changes in morphometric parameters of the gingival epithelial thickness, connective tissue papillae height and lumen diameter of arterioles, capillaries and venules in the dynamics after two, four and six weeks of experimental opioid exposure. Studies were performed on outbred white male rats. In the experiment, animals were injected with increasing opioid analgesic nalbuphine for six weeks, which ranged from 0.212 to 0.252 mg / kg. For histological and morphometric studies, semi-thin sections of the upper and lower jaws of rats were used. It was found that with the introduction of the opioid analgesic nalbuphine in increasing doses, the difference in the components of the periodontium were statistically significant compared with similar values of intact animals, indicating reactive changes in the gingival mucosa during short-term opioid action. After six weeks of opioid exposure, morphometrically revealed a sharp change in the vector of dynamics, which was manifested by statistically significant changes in the values of the components of the gums compared with similar indicators of intact animals, indicating the development of inflammatory- dystrophic changes in periodontal tissues.
Highlights
An important factor in the development of diseases of the human body is drug abuse, which leads to complete disability, mental health disorders and high mortality [2, 9, 13]
In the medical literature there is no data on the development and peculiarities of the course of the pathological process in the mucous membrane and in the hemomicrocirculatory bed of the gingiva in the dynamics at different terms of the opioid analgesic
After two weeks of the experiment it was morphometrically found that the mean values of the components of the gingival mucosa were statistically different from those of animals of the intact group, except for an insignificant increase in the thickness of the epithelium of the gingival sulcus. and venules), which was due to the action of opioid analgesics in the early stages
Summary
An important factor in the development of diseases of the human body is drug abuse, which leads to complete disability, mental health disorders and high mortality [2, 9, 13]. In opioid-dependent individuals, significant changes are observed in the tissues and organs of the oral cavity, in which the prevalence of periodontitis is ten times higher than in those who do not use narcotic substances [1, 11]. Insufficient attention is paid to the study of inflammatory processes in the oral cavity and parodontium in drug addicted individuals, and the mechanism of exposure of new narcotic substances has not been studied well [3, 14]. It should be noted that an important role in the pathomorphogenesis of periodontitis is played by the epithelium condition of the mucous membrane of the gums and vascular disorders, which are one of the primary reasons of the inflammatory-dystrophic changes in the tissues and organs of the oral cavity [4, 7, 8]. The aim of the study the dynamics of changes in morphometric parameters in the thickness of the epithelium of the gums, the height of the connective tissue papillae and the diameter of the lumen of arterioles, capillaries and venules in dynamics in two, four and six weeks of action of the opioid analgesic in the experiment
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
